Evidence map›Paper›PMID 25277969›Full record

ArticleObesity facts2014

Rats fed diets with different energy contribution from fat do not differ in adiposity.

Alexander D Miras, Florian Seyfried, Alkystis Phinikaridou, Marcelo E Andia, Ioannis Christakis, Alan C Spector, René M Botnar, Carel W le Roux

Registry-linked trialOpen access · goldAbstract readComparative Study
In one paragraph

Article in Obesity facts, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04600596 (Adherence of Reporting Energy Intake by a Novel Food Photo Recognition Dietary Assessment App on Morbid Obese Subjects Scheduled for Bariatric Surgery), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04600596 completednot on this mapstarted 2019, after this paper: background citation

Adherence of Reporting Energy Intake by a Novel Food Photo Recognition Dietary Assessment App on Morbid Obese Subjects Scheduled for Bariatric Surgery

TypeobservationalSponsorMarco BueterRan2019 to 2023Enrolled54ConditionsObesity, Morbid, Bariatric Surgery, Roux-en-Y Gastric Bypass, Food PreferencesArmsRecording of food intake.
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Sex-Dependent T Cell Dysregulation in Mice with Diet-Induced Obesity.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Alexander D MirasSection of Investigative Medicine, Imperial College London, UK.
Florian Seyfried
Alkystis Phinikaridou
Marcelo E Andia
Ioannis Christakis
Alan C Spector
René M Botnar
Carel W le Roux
Imperial College London · GBSt Thomas' Hospital · GBBritish Heart Foundation · GBFlorida State University · USUniversity of Würzburg · DE

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council G0902002
6 · The paper itself

Abstract

objectiveTo determine whether rats reaching the same body mass, having been fed either a low-fat (LFD) or a high-fat diet (HFD), differ in white adipose tissue (WAT) deposition.

methodsIn experiment 1, 22 Sprague-Dawley rats of the same age were divided into 11 rats with body mass below the batch median and fed a HFD, and 11 above the median and fed a LFD. In experiment 2, 20 Sprague-Dawley rats of the same age and starting body mass were randomised to either a HFD or LFD. When all groups reached similar final body mass, WAT was quantified using magnetic resonance imaging (MRI), dissection, and plasma leptin.

resultsIn experiment 1, both groups reached similar final body mass at the same age; in experiment 2 the HFD group reached similar final body mass earlier than the LFD group. There were no significant differences in WAT as assessed by MRI or leptin between the HFD and LFD groups in both experiments. Dissection revealed a trend for higher retroperitoneal and epididymal adiposity in the HFD groups in both experiments.

conclusionsWe conclude that at similar body mass, adiposity is independent of the macronutrient composition of the feeding regimen used to achieve it.

Indexed as

AdiposityDietEnergy IntakeWeight GainAdipose Tissue, WhiteAge FactorsAnimalsDietary FatsDiet, Fat-RestrictedDiet, High-FatEpididymisLeptinMaleObesityPeritoneumRandom AllocationDietary FatsLeptin

Identifiers

PMID25277969
PMCPMC5644822
OpenAlexW2165043006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.