ArticleJournal of the American College of Cardiology2014
Fasting levels of high-sensitivity growth hormone predict cardiovascular morbidity and mortality: the Malmö Diet and Cancer study.
Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Cardiovascular effects of growth hormone (GH) treatment on GH-deficient adults: a meta-analysis update.Pituitary · 2020Pooled it
- N-Terminal Prosomatostatin as a Risk Marker for Cardiovascular Disease and Diabetes in a General Population.The Journal of clinical endocrinology and metabolism · 2016Trial
- Deficiency of Peptidylglycine-alpha-amidating Monooxygenase, a Cause of Sarcopenic Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2025Article
- Longitudinal lipidomic signatures of all-cause and CVD mortality in American Indians: findings from the Strong Heart Study.GeroScience · 2023Article
- Growth hormone concentration and risk of all-cause and cardiovascular mortality: The REasons for Geographic And Racial Disparities in Stroke (REGARDS) study.Atherosclerosis · 2022Article
- An appetite for growth: The role of the hypothalamic - pituitary - growth hormone axis in energy balance.Journal of neuroendocrinology · 2022Review
- Circulating levels of growth hormone in postural orthostatic tachycardia syndrome.Scientific reports · 2021Article
- Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort.Scientific reports · 2021Article
- Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome.BMC cardiovascular disorders · 2020Article
- Sex-Specific Cut-Offs for High-Sensitivity Cardiac Troponin: Is Less More?Cardiovascular therapeutics · 2019Review
- Renal sulfate reabsorption in healthy individuals and renal transplant recipients.Physiological reports · 2018Article
- Growth Hormone (GH) and Cardiovascular System.International journal of molecular sciences · 2018Review
- Genetic determinants of growth hormone and GH-related phenotypes.BMC genomics · 2017Article
- A Functional Interplay between IGF-1 and Adiponectin.International journal of molecular sciences · 2017Review
- Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment.BMC cardiovascular disorders · 2017Article
- Associations Between the Serum Metabolome and All-Cause Mortality Among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study.American journal of epidemiology · 2016Article
- Cardiovascular biomarkers and sex: the case for women.Nature reviews. Cardiology · 2015Review
- Analysis of Low Frequency Protein Truncating Stop-Codon Variants and Fasting Concentration of Growth Hormone.PloS one · 2015Article
- Cardiovascular endocrinology: Growth hormone in CVD prediction--a tall order?Nature reviews. Endocrinology · 2015Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
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Abstract
backgroundBoth pathological excess and deficiency of growth hormone (GH) are associated with cardiovascular mortality.
objectivesThe goal of this study was to test whether fasting levels of growth hormone measured with a high-sensitivity assay (hs-GH) predict cardiovascular morbidity and mortality at the population level.
methodsWe studied 4,323 participants (age 46 to 68 years; mean age 58 years; 59% women) of the Swedish, population-based Malmö Diet and Cancer study examined in 1991 to 1994. Using multivariate-adjusted Cox proportional hazards models, we related baseline levels of fasting hs-GH to incidence of coronary artery disease, stroke, congestive heart failure, all-cause mortality, and cardiovascular mortality.
resultsDuring a median follow-up of 16.2 years, hs-GH (hazard ratio [HR]/SD increment of natural logarithm of fasting hs-GH) was independently associated with increased risk of coronary artery disease (397 events; HR: 1.11; 95% confidence interval [CI]: 1.01 to 1.23; p = 0.04), stroke (251 events; HR: 1.18; 95% CI: 1.04 to 1.34; p = 0.01), congestive heart failure (107 events; HR: 1.25; 95% CI: 1.03 to 1.52; p = 0.02), all-cause mortality (645 events; HR: 1.17; 95% CI: 1.08 to 1.26; p < 0.001) and cardiovascular mortality (186 events; HR: 1.43; 95% CI: 1.24 to 1.66; p < 0.001). The addition of hs-GH to a model with conventional cardiovascular risk factors significantly reclassified risk, with a category-free net reclassification improvement (>0) of 0.542 (95% CI: 0.205 to 0.840) in cardiovascular mortality.
conclusionsHigher values of hs-GH were associated with an increased risk of cardiovascular morbidity and mortality.
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Registered trials
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