Evidence map›Paper›PMID 25277506›Full record

ArticleAnnals of epidemiology2014

Elevated hepatic enzymes and incidence of venous thromboembolism: a prospective study.

Aaron R Folsom, Pamela L Lutsey, Nicholas S Roetker, Wayne D Rosamond, Mariana Lazo, Susan R Heckbert, Saonli Basu, Mary Cushman, Elizabeth Selvin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Aaron R FolsomDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis. Electronic address: folso001@umn.edu.
Pamela L LutseyDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis.
Nicholas S RoetkerDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis.
Wayne D RosamondDepartment of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill.
Mariana LazoDivision of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle.
Saonli BasuDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis.
Mary CushmanDepartment of Medicine, University of Vermont, Burlington; Department of Pathology, University of Vermont, Burlington.
Elizabeth SelvinDivision of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
University of Minnesota · USJohns Hopkins University · USUniversity of North Carolina at Chapel Hill · USUniversity of Vermont · USUniversity of Washington · US

Funding

Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Diabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4M
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL059367NIDDK NIH HHS R01 DK089174
6 · The paper itself

Abstract

purposeApproximately 10% of the general population has elevated blood concentrations of hepatic enzymes, which are linked to increased coagulation markers. We tested whether elevated hepatic enzymes are associated with increased risk of venous thromboembolism (VTE).

methodsWe followed 12,604 adults with measurements of alanine transaminase, aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) prospectively for VTE occurrence.

resultsAST and GGT above the laboratory normal values were associated over two decades of follow-up with increased risk of total (n = 532) and provoked VTE (n = 332), but with not unprovoked VTE (n = 200). In a model adjusted for age, race, sex, hormone replacement, alcohol intake, diabetes, body mass index, estimated glomerular filtration rate, and C-reactive protein, the hazard ratios (HR) (95% confidence interval) for high versus normal AST were 1.46 (1.00-2.11) for total VTE and 1.83 (1.21-2.79) for provoked VTE. For high GGT, the HR were 1.34 (1.06-1.69) for total VTE and 1.43 (1.07-1.91) for provoked VTE. When follow-up was limited to the first 10 years, associations were even stronger (HR ≈ 1.7 for total VTE).

conclusionsElevated concentrations of two hepatic enzymes (AST and GGT) in this general middle-aged population are associated with a modestly increased risk of VTE.

Indexed as

Age FactorsAlanine TransaminaseAlcohol DrinkingAspartate AminotransferasesBody Mass IndexDiabetes MellitusFemalegamma-GlutamyltransferaseHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsVenous ThromboembolismAlanine TransaminaseAspartate Aminotransferasesgamma-GlutamyltransferaseCohort studyLiver enzymesPulmonary embolusRisk factorsVenous thrombosis

Identifiers

PMID25277506
PMCPMC4254154
OpenAlexW2165736653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.