ArticleBMC genomics2014
Transcriptome reconstruction and annotation of cynomolgus and African green monkey.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- The epitranscriptome of Vero cells infected with SARS-CoV-2 assessed by direct RNA sequencing reveals m6A pattern changes and DRACH motif biases in viral and cellular RNAs.Frontiers in cellular and infection microbiology · 2022Article
- Signature MicroRNA expression profile is associated with lipid metabolism in African green monkey.Lipids in health and disease · 2019Article
- Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues.BMC genomics · 2018Article
- Successful application of human-based methyl capture sequencing for methylome analysis in non-human primate models.BMC genomics · 2018Article
- A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever.Science translational medicine · 2018Article
- Host Transcriptional Response to Ebola Virus Infection.Vaccines · 2017Review
- Genomic Tools for the Use of Nonhuman Primates in Translational Research.ILAR journal · 2017Review
- Article
- Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description.Immunogenetics · 2016Article
- De novo transcriptome reconstruction and annotation of the Egyptian rousette bat.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNon-human primates (NHPs) and humans share major biological mechanisms, functions, and responses due to their close evolutionary relationship and, as such, provide ideal animal models to study human diseases. RNA expression in NHPs provides specific signatures that are informative of disease mechanisms and therapeutic modes of action. Unlike the human transcriptome, the transcriptomes of major NHP animal models are yet to be comprehensively annotated.
resultsIn this manuscript, employing deep RNA sequencing of seven tissue samples, we characterize the transcriptomes of two commonly used NHP animal models: Cynomolgus macaque (Macaca fascicularis) and African green monkey (Chlorocebus aethiops). We present the Multi-Species Annotation (MSA) pipeline that leverages well-annotated primate species and annotates 99.8% of reconstructed transcripts. We elucidate tissue-specific expression profiles and report 13 experimentally validated novel transcripts in these NHP animal models.
conclusionWe report comprehensively annotated transcriptomes of two non-human primates, which we have made publically available on a customized UCSC Genome Browser interface. The MSA pipeline is also freely available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.