ReviewNeuroscience and biobehavioral reviews2014
Autism, oxytocin and interoception.
Review in Neuroscience and biobehavioral reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
165 citing papers in PubMed, 2 syntheses or guidelines pooled it, 400 citations in OpenAlex.
- Interoception in individuals with autism spectrum disorder: a systematic literature review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- An interoceptive model of bulimia nervosa: A neurobiological systematic review.Journal of psychiatric research · 2017Pooled it
- Oxytocin modulates local topography of human functional connectome in healthy men at rest.Communications biology · 2021Trial
- Functional neuroanatomy of interoceptive processing in children and adolescents: a pilot study.Scientific reports · 2019Trial
- Oxytocin Modulates Attention Switching Between Interoceptive Signals and External Social Cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Electrophysiological correlates of oxytocin-induced enhancement of social performance monitoring.Social cognitive and affective neuroscience · 2017Trial
- Working hard for oneself or others: Effects of oxytocin on reward motivation in social anxiety disorder.Biological psychology · 2017Trial
- The oxytocinergic system in functional neurological disorder: Preliminary testing of associations with interoception and childhood trauma.Comprehensive psychoneuroendocrinology · 2026Article
- The Relationship Between Interoception, Alexithymia, Autistic Traits and Eating Pathology in Autistic Adults.Journal of autism and developmental disorders · 2026Article
- Associations between anterior hypothalamic subunits and ADHD and autistic traits revealed by deep learning MRI segmentation.Discover mental health · 2026Article
- A Developmental Neuroimmune Cascade Model of Autism Spectrum Disorder.International journal of molecular sciences · 2026Review
- A Network Analysis of Alexithymia, Interoception, Empathy, Self-Awareness and Psychopathological Symptoms in Young People With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Associations Between Autism and Self-Reported Dimensions of Interoception.Autism : the international journal of research and practice · 2026Article
- A Theoretical Framework for Studying the Phenomenon of Gaslighting.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2026Review
- Exploring the autism and functional neurological disorder association: Considerations from biopsychosocial, neuropsychological and computational models.Autism : the international journal of research and practice · 2026Review
- Development of interoception: the critical role of maternal affective touch in early attachment.Frontiers in neuroscience · 2026Article
- Increased salivary oxytocin correlates with lower self-reported interoceptive accuracy in functional neurological disorders.Neurobiology of stress · 2025Article
- Feasibility of the heaviness perception test as an assessment of interoception.BioPsychoSocial medicine · 2025Article
- It Is Movement All the Way Down: Broken Rhythms and Embodied Selfhood in Depersonalization.Behavioral sciences (Basel, Switzerland) · 2025Article
- Disrupted diencephalon development and neuropeptidergic pathways in zebrafish with autism-risk mutations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Autism is a pervasive developmental disorder characterized by profound social and verbal communication deficits, stereotypical motor behaviors, restricted interests, and cognitive abnormalities. Autism affects approximately 1% of children in developing countries. Given this prevalence, identifying risk factors and therapeutic interventions are pressing objectives—objectives that rest on neurobiologically grounded and psychologically informed theories about the underlying pathophysiology. In this article, we review the evidence that autism could result from a dysfunctional oxytocin system early in life. As a mediator of successful procreation, not only in the reproductive system, but also in the brain, oxytocin plays a crucial role in sculpting socio-sexual behavior. Formulated within a (Bayesian) predictive coding framework, we propose that oxytocin encodes the saliency or precision of interoceptive signals and enables the neuronal plasticity necessary for acquiring a generative model of the emotional and social 'self.' An aberrant oxytocin system in infancy could therefore help explain the marked deficits in language and social communication—as well as the sensory, autonomic, motor, behavioral, and cognitive abnormalities—seen in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.