ArticleAAPS PharmSciTech2015
Development and characterization of sorbitan monostearate and sesame oil-based organogels for topical delivery of antimicrobials.
Article in AAPS PharmSciTech, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 93 citations in OpenAlex.
- Vegetable Oil-Based Materials for Drug Delivery Systems and Wound Dressings.Macromolecular bioscience · 2026Review
- Supramolecular Organogels Based on Cinnarizine as a Potential Gastroretentive System: In Vitro and In Silico Simulations.Gels (Basel, Switzerland) · 2026Article
- Influence of Choline-Based Ionogel on Transdermal Delivery of Vancomycin Hydrochloride.Molecular pharmaceutics · 2025Article
- Mucoadhesive Polymeric Polyologels Designed for the Treatment of Periodontal and Related Diseases of the Oral Cavity.Polymers · 2024Article
- Organogels: "GelVolution" in Topical Drug Delivery - Present and Beyond.Current pharmaceutical design · 2024Review
- Characterization of mixed-component oleogels: Beeswax and glycerol monostearate interactions towardsCurrent research in food science · 2024Article
- Novel Organogels fromPharmaceutics · 2023Article
- Fabrication of Stable Oleofoams with Sorbitan Ester Surfactants.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris.Polymers · 2022Article
- Preformulation and characterization of raloxifene-loaded lipid nanoparticles for transdermal administration.Drug delivery and translational research · 2022Article
- Development of Antioxidant-Fortified Oleogel and Its Application as a Solid Fat Replacer to Muffin.Foods (Basel, Switzerland) · 2021Article
- Application of Analytical Methods for the Comprehensive Analysis of Oleogels-A Review.Polymers · 2021Review
- Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability.Polymers · 2021Article
- A garlic oil-based organo-hydrogel for use in pH-sensitive drug release.Chemicke zvesti · 2021Article
- Synthesis and characterization of novel organo-hydrogel based agar, glycerol and peppermint oil as a natural drug carrier/release material.Materials science & engineering. C, Materials for biological applications · 2021Article
- In vitro release of hydrophobic drugs by oleogel rods with biocompatible gelators.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020Article
- Novel oleogel formulation based on amaranth oil: Physicochemical characterization.Food science & nutrition · 2019Article
- Effect of silicone oil on the microstructure, gelation and rheological properties of sorbitan monostearate-sesame oil oleogels.Asian journal of pharmaceutical sciences · 2018Article
- Carbohydrate Derived Organogelators and the Corresponding Functional Gels Developed in Recent Time.Gels (Basel, Switzerland) · 2018Review
- Controlling Agglomeration of Protein Aggregates for Structure Formation in Liquid Oil: A Sticky Business.ACS applied materials & interfaces · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study explains the development of sorbitan monostearate and sesame oil-based organogels for topical drug delivery. The organogels were prepared by dissolving sorbitan monostearate in sesame oil (70°C). Metronidazole was used as a model antimicrobial. The formulations were characterized using phase contrast microscopy, infrared spectroscopy, viscosity, mechanical test, and differential scanning calorimetry. Phase contrast microscopy showed the presence of needle-shaped crystals in the organogel matrix. The length of the crystals increased with the increase in the sorbitan monostearate concentration. XRD studies confirmed the amorphous nature of the organogels. Viscosity study demonstrated shear thinning behavior of the organogels. The viscosity and the mechanical properties of the organogels increased linearly with the increase in the sorbitan monostearate concentration. Stress relaxation study confirmed the viscoelastic nature of the organogels. The organogels were biocompatible. Metronidazole-loaded organogels were examined for their controlled release applications. The release of the drug followed zero-order release kinetics. The drug-loaded organogels showed almost similar antimicrobial activity against Escherichia coli when compared to the commercially available Metrogyl® gel. In gist, it can be proposed that the developed organogels had sufficient properties to be used for controlled delivery of drugs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.