ArticleOncotarget2014
A central role for TRPS1 in the control of cell cycle and cancer development.
Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Single-cell profiling decodes patagium development in gliding mammal.Nature communications · 2026Article
- Trps1 regulates mouse zygotic genome activation and preimplantation embryo development via the PDE4D/AKT/CREB signaling pathway.Cell biology and toxicology · 2025Article
- Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan.International journal of molecular sciences · 2023Article
- Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats.Frontiers in toxicology · 2023Article
- Clinical significance and biological function of transcriptional repressor GATA binding 1 in gastric cancer: a study based on data mining, RT-qPCR, immunochemistry, and vitro experiment.Cell cycle (Georgetown, Tex.) · 2020Article
- TRPS1 Confers Multidrug Resistance of Breast Cancer Cells by Regulating BCRP Expression.Frontiers in oncology · 2020Article
- LncRNA PVT1 Regulates TRPS1 Expression in Breast Cancer by Sponging miR-543.Cancer management and research · 2020Article
- An Effective Graph Clustering Method to Identify Cancer Driver Modules.Frontiers in bioengineering and biotechnology · 2020Article
- Article
- Folate Repletion after Deficiency Induces Irreversible Genomic and Transcriptional Changes in Human Papillomavirus Type 16 (HPV16)-Immortalized Human Keratinocytes.International journal of molecular sciences · 2019Article
- Novel PLAG1 Gene Rearrangement Distinguishes a Subset of Uterine Myxoid Leiomyosarcoma From Other Uterine Myxoid Mesenchymal Tumors.The American journal of surgical pathology · 2019Article
- Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo.Cell cycle (Georgetown, Tex.) · 2019Article
- Article
- Transcriptional repressor GATA binding 1-mediated repression of SRY-box 2 expression suppresses cancer stem cell functions and tumor initiation.The Journal of biological chemistry · 2018Article
- Article
- Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth.Breast cancer research : BCR · 2018Article
- Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression.Cancer medicine · 2018Article
- TRPS1 Suppresses Breast Cancer Epithelial-mesenchymal Transition Program as a Negative Regulator of SUZ12.Translational oncology · 2018Article
- Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer.Oncogene · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The eukaryotic cell cycle is controlled by a complex regulatory network, which is still poorly understood. Here we demonstrate that TRPS1, an atypical GATA factor, modulates cell proliferation and controls cell cycle progression. Silencing TRPS1 had a differential effect on the expression of nine key cell cycle-related genes. Eight of these genes are known to be involved in the regulation of the G2 phase and the G2/M transition of the cell cycle. Using cell synchronization studies, we confirmed that TRPS1 plays an important role in the control of cells in these phases of the cell cycle. We also show that silencing TRPS1 controls the expression of 53BP1, but not TP53. TRPS1 silencing also decreases the expression of two histone deacetylases, HDAC2 and HDAC4, as well as the overall HDAC activity in the cells, and leads to the subsequent increase in the acetylation of histone4 K16 but not of histone3 K9 or K18. Finally, we demonstrate that TRPS1 expression is elevated in luminal breast cancer cells and luminal breast cancer tissues as compared with other breast cancer subtypes. Overall, our study proposes that TRPS1 acts as a central hub in the control of cell cycle and proliferation during cancer development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.