ArticleBMC musculoskeletal disorders2014
Local control of giant cell tumors of the long bone after aggressive curettage with and without bone cement.
Article in BMC musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Pre-operative denosumab is associated with higher risk of local recurrence in giant cell tumor of bone: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2020Pooled it
- Current status of bone cementing and bone grafting for giant cell tumour of bone: a systemic review.Annals of the Royal College of Surgeons of England · 2019Pooled it
- Return to Sport and High-Demanding Activities After Curettage for Benign and Locally Aggressive Bone Tumors.Journal of clinical medicine · 2026Article
- Comparative analysis of aggressiveness in giant cell tumor of bone between upper and lower extremities: A systematic review and meta-analysis.Journal of bone oncology · 2025Review
- A Review on Bone Tumor Management: Cutting-Edge Strategies in Bone Grafting, Bone Graft Substitute, and Growth Factors for Defect Reconstruction.Orthopedic research and reviews · 2025Review
- Review
- Giant cell tumor of bone: A single center study of 115 cases.Journal of bone oncology · 2022Article
- Benign Bone Tumors: An Overview of What We Know Today.Journal of clinical medicine · 2022Review
- Imaging following surgery for primary appendicular bone tumours.Skeletal radiology · 2021Review
- The impact of curettage technique on local control in giant cell tumour of bone.International orthopaedics · 2021Review
- Management of the Cavity After Removal of Giant Cell Tumor of the Bone.Frontiers in surgery · 2021Review
- Joint preservation surgery in grade 2 and 3 giant cell tumors of bone around the knee.SICOT-J · 2021Article
- Giant Cell Tumour Around Knee Managed by Curettage and Zoledronic Acid with Structural Support by Fibula Cortical Struts.Malaysian orthopaedic journal · 2020Article
- Mid-term results of intralesional extended curettage, cauterization, and polymethylmethacrylate cementation in the treatment of giant cell tumor of bone: A retrospective case series.Acta orthopaedica et traumatologica turcica · 2020Observational
- Epidemiologic Characteristics, Clinical Behavior, and Outcome of the Giant Cell Tumor of the Bone: A Retrospective Single-center Study.The archives of bone and joint surgery · 2019Article
- Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone.Current opinion in oncology · 2019Review
- Retrospective analysis of 51 intralesionally treated cases with progressed giant cell tumor of the bone: local adjuvant use of hydrogen peroxide reduces the risk for tumor recurrence.World journal of surgical oncology · 2019Article
- Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study.World journal of surgical oncology · 2018Article
- CORR InsightsClinical orthopaedics and related research · 2017Article
- Clinical and pathological results of denosumab treatment for giant cell tumors of bone: Prospective study of 14 cases.Acta orthopaedica et traumatologica turcica · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAggressive curettage has been well established for the treatment of giant cell tumors (GCTs) of the bone. The purpose of this study was to review our experience and evaluate the role of different implant materials in patients with GCTs of the extremities after aggressive curettage.
methodsA total of 119 patients with GCTs of the long bone were treated at the First Affiliated Hospital of Sun Yat-Sen University between 2004 and 2009. We excluded patients presenting metastases, recurrent tumors, and soft tissue involvement and those with Jaffe pathological grade III. The remaining 65 patients were treated with aggressive curettage using a bone graft or bone cement to fill the cavity. The recurrence rates and functional scores associated with the different fillings were analyzed.
resultsAggressive curettage and bone grafting was performed in 34 cases (52.3%), and aggressive curettage with bone cement was performed in 31 cases (47.7%). The overall recurrence rate after the aggressive intralesional procedures was 35.3% with bone grafting and 12.9% when bone cement was used as an adjuvant filling. The recurrence rate following aggressive curettage and bone grafting was higher than that following aggressive curettage with cement (p = 0.038). The Musculoskeletal Tumor Society (MSTS) score for bone graft patients was 91.1%, which was significantly lower than that for patients treated with bone cement (94.7%).
conclusionsThe use of bone cement was associated with a significantly lower recurrence rate than bone grafting following aggressive intralesional curettage to treat benign giant cell tumors of the long bone. Better MSTS functional results were also observed in the bone cement group compared to the bone graft group.
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