ArticleBioMed research international2014
Gene expression profiling of biological pathway alterations by radiation exposure.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Genome-wide transcriptomic response of whole blood to radiation.Scientific reports · 2025Article
- Population Studies and Molecular Mechanisms of Human Radioadaptive Capabilities: Is It Time to Rethink Radiation Safety Standards?International journal of molecular sciences · 2024Review
- Metabolomics and transcriptomics based multi-omics integration reveals radiation-induced altered pathway networking and underlying mechanism.NPJ systems biology and applications · 2023Article
- Postsynaptic density radiation signature following space irradiation.Frontiers in physiology · 2023Article
- Transcriptomic profiling reveals gene expression in human peripheral blood after exposure to low-dose ionizing radiation.Journal of radiation research · 2022Article
- Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome.Scientific reports · 2021Article
- Generation of a Transcriptional Radiation Exposure Signature in Human Blood Using Long-Read Nanopore Sequencing.Radiation research · 2020Article
- Distinct vascular genomic response of proton and gamma radiation-A pilot investigation.PloS one · 2019Article
- Comparison of Serum Metabolite Changes of Radiated Mice Administered withMolecules (Basel, Switzerland) · 2018Article
- Dose-Response Curves of theIranian Red Crescent medical journal · 2016Article
- Suppression of CD4+ Effector Responses by Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells Contributes to Experimental Cerebral Malaria.Infection and immunity · 2016Article
- MicroRNA expression profiling altered by variant dosage of radiation exposure.BioMed research international · 2014Article
- The Potential Effect of Different Doses of Ionizing Radiation on Genes and Disease.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted. Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiation, followed by array-based expression profiling. Gene set enrichment analysis indicated that the immune system and cancer development pathways appeared to be the major affected targets by radiation exposure. Therefore, 1 Gy radioactive exposure seemed to be a critical threshold dosage. In fact, after 1 Gy radiation exposure, expression levels of several genes including FADD, TNFRSF10B, TNFRSF8, TNFRSF10A, TNFSF10, TNFSF8, CASP1, and CASP4 that are associated with carcinogenesis and metabolic disorders showed significant alterations. Our results suggest that exposure to low-dose radiation may elicit changes in metabolic and immune pathways, potentially increasing the risk of immune dysfunctions and metabolic disorders.
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