ArticleBioMed research international2014
Serum metal ion concentrations in paediatric patients following total knee arthroplasty using megaprostheses.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Metal ion exposure after oncologic megaprosthesis salvage surgery: a systematic review.Journal of bone oncology · 2026Article
- Highly Elevated Metal Ion Levels After Tumor Resections and Reconstruction With Megaprostheses Around the Knee.Clinical orthopaedics and related research · 2025Article
- Secondary Infection of Adverse Local Tissue Reaction Leading to Amputation in a Patient With a Modular Knee Endoprosthesis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- CORR Insights®: Taper Junction Subsidence Occurs in Modular Tumor Endoprostheses: How Concerned Should We Be?Clinical orthopaedics and related research · 2025Article
- Taper Junction Subsidence Occurs in Modular Tumor Endoprostheses: How Concerned Should We Be?Clinical orthopaedics and related research · 2025Article
- Elevated cobalt levels in metal-on-polyethylene knee megaprostheses: a prospective 1-year cohort study of 56 patients with hip and knee megaprostheses.Acta orthopaedica · 2024Article
- Systemic Metal Ion Concentrations in Patients With Hip and Knee Megaprostheses: A Prospective Cohort Study.Arthroplasty today · 2022Article
- Long-Term Effects of Metal-on-Metal Cobalt-Chromium-Containing Prostheses Used in Total Knee Arthroplasty on Hearing and Tinnitus.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Retrieval Analysis of Modern Knee Tumor Megaendoprosthesis Shows Considerable Volumetric Metal Wear Generated at the Rotating Hinge.Materials (Basel, Switzerland) · 2020Article
- CORR Insights®: Are Serum Metal Ion Levels a Concern at Mid-term Followup of Revision Knee Arthroplasty With a Metal-on-metal Hinge Design?Clinical orthopaedics and related research · 2019Article
- Are Serum Metal Ion Levels a Concern at Mid-term Followup of Revision Knee Arthroplasty With a Metal-on-metal Hinge Design?Clinical orthopaedics and related research · 2019Article
- Cobalt in athletes: hypoxia and doping - new crossroads.Journal of applied biomedicine · 2019Review
- Local Biological Reactions and Pseudotumor-Like Tissue Formation in relation to Metal Wear in a Murine In Vivo Model.BioMed research international · 2019Article
- Article
- Metallic ion release after knee prosthesis implantation: a prospective study.International orthopaedics · 2017Article
- Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma.Skeletal radiology · 2017Article
- High blood metal ion levels in 19 of 22 patients with metal-on-metal hinge knee replacements.Acta orthopaedica · 2017Article
- Clinical Results and Serum Metal Ion Concentrations following Ceramic-on-Metal Total Hip Arthroplasty at a Mean Follow-Up of 60 Months.BioMed research international · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine the concentrations of cobalt, chromium, and molybdenum in the serum of paediatric tumour patients after fixed hinge total knee arthroplasty. Further, these metal ion levels were compared with serum metal ion levels of patients with other orthopaedic devices such as hip and knee prostheses with metal-on-metal or metal-on-polyethylene articulation to find differences between anatomical locations, abrasion characteristics, and bearing surfaces. After an average follow-up of 108 months (range: 67 to 163) of 11 paediatric patients with fixed hinge total knee arthroplasty, the mean concentrations for Co and Cr were significantly increased while Mo was within the limits compared to the upper values from the reference laboratory. Furthermore, these serum concentrations were significantly higher compared to patients with a standard rotating hinge device (P = 0.002 and P < 0.001) and preoperative controls (P < 0.001). On the other hand, the serum levels of patients following MoM THA or rotating hinge arthroplasty using megaprostheses were higher. Therefore, periodic long-term follow-ups are recommended due to the rising concerns about systemic metal ion exposure in the literature. Upon the occurrence of adverse reactions to metal debris the revision of the fixed hinge implant should be considered.
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