Evidence map›Paper›PMID 25276814›Full record

ArticleBioMed research international2014

Hyaluronan-phosphatidylethanolamine polymers form pericellular coats on keratinocytes and promote basal keratinocyte proliferation.

Caitlin J Symonette, Aman Kaur Mann, Xiao Cherie Tan, Cornelia Tolg, Jenny Ma, Francisco Perera, Arjang Yazdani, Eva A Turley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Hyaluronic Acid ProfhiloMedicina (Kaunas, Lithuania) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Caitlin J SymonetteDivision of Plastic and Reconstructive Surgery, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 3K7.
Aman Kaur MannLondon Regional Cancer Program, London Health Sciences Centre, Room A4-931A, 790 Commissioners Road East, London, ON, Canada N6A 4L6.ORCID 0000-0001-5958-7051
Xiao Cherie TanLondon Regional Cancer Program, London Health Sciences Centre, Room A4-931A, 790 Commissioners Road East, London, ON, Canada N6A 4L6.
Cornelia TolgLondon Regional Cancer Program, London Health Sciences Centre, Room A4-931A, 790 Commissioners Road East, London, ON, Canada N6A 4L6.
Jenny MaLondon Regional Cancer Program, London Health Sciences Centre, Room A4-931A, 790 Commissioners Road East, London, ON, Canada N6A 4L6.
Francisco PereraLondon Regional Cancer Program, London Health Sciences Centre, Room A4-931A, 790 Commissioners Road East, London, ON, Canada N6A 4L6.
Arjang YazdaniDivision of Plastic and Reconstructive Surgery, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 3K7 ; London Health Science Center, Victoria Hospital, Room E2-647, 800 Commissioners Road East, London, ON, Canada N6A 4G5.ORCID 0000-0001-9865-283X
Eva A TurleyDivision of Plastic and Reconstructive Surgery, University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 3K7 ; London Regional Cancer Program, London Health Sciences Centre, Room A4-931A, 790 Commissioners Road East, London, ON, Canada N6A 4L6.
London Health Sciences Centre · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aged keratinocytes have diminished proliferative capacity and hyaluronan (HA) cell coats, which are losses that contribute to atrophic skin characterized by reduced barrier and repair functions. We formulated HA-phospholipid (phosphatidylethanolamine, HA-PE) polymers that form pericellular coats around cultured dermal fibroblasts independently of CD44 or RHAMM display. We investigated the ability of these HA-PE polymers to penetrate into aged mouse skin and restore epidermal function in vivo. Topically applied Alexa(647)-HA-PE penetrated into the epidermis and dermis, where it associated with both keratinocytes and fibroblasts. In contrast, Alexa(647)-HA was largely retained in the outer cornified layer of the epidermis and quantification of fluorescence confirmed that significantly more Alexa(647)-HA-PE penetrated into and was retained within the epidermis than Alexa(647)-HA. Multiple topical applications of HA-PE to shaved mouse skin significantly stimulated basal keratinocyte proliferation and epidermal thickness compared to HA or vehicle cream alone. HA-PE had no detectable effect on keratinocyte differentiation and did not promote local or systemic inflammation. These effects of HA-PE polymers are similar to those reported for endogenous epidermal HA in youthful skin and show that topical application of HA-PE polymers can restore some of the impaired functions of aged epidermis.

Indexed as

Administration, TopicalAnimalsCell DifferentiationCell ProliferationCells, CulturedEpidermal CellsEpidermisExtracellular Matrix ProteinsFemaleFibroblastsHyaluronan ReceptorsHyaluronic AcidInflammationKeratinocytesMice, Inbred C57BLPhosphatidylethanolaminesExtracellular Matrix Proteinshyaluronan-mediated motility receptorHyaluronan ReceptorsHyaluronic AcidphosphatidylethanolaminePhosphatidylethanolaminesPolymers

Identifiers

PMID25276814
PMCPMC4172883
OpenAlexW2018267346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.