Evidence map›Paper›PMID 25276784›Full record

ReviewBioMed research international2014

Management of non-vitamin K antagonist oral anticoagulants in the perioperative setting.

Anne-Sophie Dincq, Sarah Lessire, Jonathan Douxfils, Jean-Michel Dogné, Maximilien Gourdin, François Mullier

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Perioperative management of anticoagulant therapy.Innovative surgical sciences · 2019
    Review
  3. Article
  4. [Perioperative handling of anticoagulation].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018
    Review
  5. Observational
  6. Review
  7. Implications of apixaban for dental treatments.Journal of clinical and experimental dentistry · 2016
    Review
  8. What's New in Anticoagulation.Texas Heart Institute journal · 2016
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anne-Sophie DincqDepartment of Anesthesiology, CHU Dinant Godinne UcL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute of Life Sciences (NARILIS), 5530 Yvoir, Belgium.
Sarah LessireDepartment of Anesthesiology, CHU Dinant Godinne UcL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute of Life Sciences (NARILIS), 5530 Yvoir, Belgium ; Department of Pharmacy, University of Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute of Life Sciences (NARILIS), 5000 Namur, Belgium.ORCID 0000-0001-6689-6100
Jonathan DouxfilsDepartment of Pharmacy, University of Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute of Life Sciences (NARILIS), 5000 Namur, Belgium.ORCID 0000-0002-7644-5298
Jean-Michel DognéDepartment of Pharmacy, University of Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute of Life Sciences (NARILIS), 5000 Namur, Belgium.
Maximilien GourdinDepartment of Anesthesiology, CHU Dinant Godinne UcL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute of Life Sciences (NARILIS), 5530 Yvoir, Belgium.
François MullierHaematology Laboratory, CHU Dinant Godinne UcL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute of Life Sciences (NARILIS), 5530 Yvoir, Belgium.ORCID 0000-0001-6947-6099
CHU Dinant Godinne UCL Namur · BEUniversity of Namur · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The field of oral anticoagulation has evolved with the arrival of non-vitamin K antagonist oral anticoagulants (NOACs) including an anti-IIa agent (dabigatran etexilate) and anti-Xa agents (rivaroxaban and apixaban). The main specificities of these drugs are predictable pharmacokinetics and pharmacodynamics but special attention should be paid in the elderly, in case of renal dysfunction and in case of emergency. In addition, their perioperative management is challenging, especially with the absence of specific antidotes. Effectively, periods of interruption before surgery or invasive procedures depend on half-life and keeping a permanent balance between bleeding and thromboembolic risks. In addition, few data regarding the link between plasma concentrations and their effects are provided. Routine laboratory tests are altered by NOACs and quantitative measurements are not widely performed. This paper provides a review on the management of NOACs in the perioperative setting, including the estimation of the bleeding and thrombotic risk, the periods of interruption, the indication of heparin bridging, the usefulness of laboratory tests before surgery or invasive procedure, and the time of resuming. Most data are based on expert's opinions.

Indexed as

Perioperative CareAdministration, OralAnticoagulantsClinical Laboratory TechniquesDrug InteractionsHumansVitamin KAnticoagulantsVitamin K

Identifiers

PMID25276784
PMCPMC4168027
OpenAlexW2122652283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.