ReviewCardiovascular diagnosis and therapy2014
Molecular mechanisms of vascular dysfunction and cardiovascular biomarkers in type 2 diabetes.
Review in Cardiovascular diagnosis and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Plant by-products as a valuble source of natural antiglycemic compounds: Economic aspects and alternative raw material sources.Journal of food and drug analysis · 2026Review
- Molecular Pathways of Cardiometabolic Residual Risk in Type 2 Diabetes: Insulin Resistance, Metaflammation, and Liver-Kidney-Vascular Crosstalk.International journal of molecular sciences · 2026Review
- Significance of Singlet Oxygen Molecule in Pathologies.International journal of molecular sciences · 2023Review
- Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy.Current issues in molecular biology · 2022Review
- Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2022Review
- Efficacy of flaxseed oil compared with fish oil supplementation in the treatment of coronary heart disease: a retrospective study.Journal of thoracic disease · 2022Article
- Article
- Prevention of Vascular Calcification by Magnesium and Selected Polyphenols.Advances in preventive medicine · 2021Article
- The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process.Cells · 2020 · on this mapReview
- The 12-HHT/BLT2/NO Axis Is Associated to the Wound Healing and Skin Condition in Different Glycaemic States.Medical sciences (Basel, Switzerland) · 2019Article
- A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats.Acta pharmacologica Sinica · 2017Article
- BLT2 expression improves skin integrity and protects from alterations caused by hyperglycemia in type 2 diabetes.Dermato-endocrinology · 2017Article
- Mechanisms of ectopic calcification: implications for diabetic vasculopathy.Cardiovascular diagnosis and therapy · 2015Review
- Diabetes and cardiovascular disease: let's push forward with translational research.Cardiovascular diagnosis and therapy · 2015Article
- Hyperglycemia: a bad signature on the vascular system.Cardiovascular diagnosis and therapy · 2015Article
- Atrial fibrillation in patients with diabetes: molecular mechanisms and therapeutic perspectives.Cardiovascular diagnosis and therapy · 2015Review
- Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications.Journal of diabetes research · 2015Review
- The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes.Frontiers in endocrinology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prevalence of obesity and type 2 diabetes (T2DM) is alarmingly increasing worldwide. Albeit advances in therapy have reduced morbidity and mortality in T2DM, cardiovascular risk is far to be eradicated and mechanism-based therapeutic approaches are in high demand. In this perspective, deciphering novel molecular networks of vascular disease will be instrumental to develop novel diagnostic and therapeutic strategies in people affected by diabetes. There is therefore a need to address current knowledge gaps in disease aetiology in order to support innovation in diagnosis and treatment. Unfortunately, we are still lacking cost-effective markers able to identify atherosclerotic vascular disease at an early stage. The issue of risk stratification deserves attention because not every T2DM patient carries the same degree of inflammation and oxidative stress. The diversity of metabolic phenotypes with different outcomes underscores the need for cardiovascular risk stratification within such heterogeneous population. Early predictors of vascular damage are mandatory to implement intensive treatment strategies and, hence, reduce cardiovascular disease burden in this setting. In this review we critically discuss novel molecular mechanisms of diabetic vascular disease and their possible translation to the clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.