ArticleAnatomy & cell biology2014
Effect of saffron (Crocus sativus L.) on sodium valporate induced cytogenetic and testicular alterations in albino rats.
Article in Anatomy & cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- The Therapeutic Effects ofHealth science reports · 2026Article
- Effects of Moringa oleifera extract on biochemical and histological parameters of sodium valproate induced lungs damage.Journal of molecular histology · 2024Article
- Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management.Cellular and molecular life sciences : CMLS · 2020Review
- Valproic acid induces histologic changes and decreases androgen receptor levels of testis and epididymis in rats.International journal of reproductive biomedicine · 2017Article
- Chronic restraint stress induces sperm acrosome reaction and changes in testicular tyrosine phosphorylated proteins in rats.International journal of reproductive biomedicine · 2016Article
- Changes of testicular phosphorylated proteins in response to restraint stress in male rats.Journal of Zhejiang University. Science. B · 2016Article
- Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the cytogenetic and testicular damage induced by the antiepileptic drug, sodium valporate (SVP) in albino rats and the effect of saffron aqueous extracts. Treating rats with SVP caused a significant increase in the chromosomal aberrations either structural or numerical and decreased the mitotic index. Besides, animals administered SVP showed DNA damage appeared in the single strand breaks (comet assay). Testis of SVP-treated rats showed many histopathological changes. A significant decrease in seminiferous tubules and their epithelial heights diameters and inhibition of spermatogenesis was recorded. In addition, the number of sperm head abnormalities was increased. Biochemical results revealed an increase in malondialdhyde (MDA) which is lipid peroxidation marker and a significant decrease in the level of serum antioxidant enzyme, catalase (CAT) and reducing antioxidant power (RAP). Animals given SVP and saffron showed an improvement in chromosomal aberrations, mitotic index, DNA damage and testicular alterations caused by SVP. Moreover, MDA decreased and CAT and RAP increased. It is concluded from the present results that the ameliorative effects of saffron extract against SVP-induced cytogenetic and testicular damage in albino rats may be due to the presence of one or more antioxidant components of saffron.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.