Evidence map›Paper›PMID 25276369›Full record

ArticleJournal of thoracic disease2014

Effects of different LAD-blocked sites on the development of acute myocardial infarction and malignant arrhythmia in a swine model.

Xiaorong Li, Danbing Shao, Gannan Wang, Ting Jiang, Honghao Wu, Bing Gu, Kejiang Cao, Jinsong Zhang, Lianwen Qi, Yan Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaorong Li1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Danbing Shao1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Gannan Wang1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Ting Jiang1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Honghao Wu1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Bing Gu1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Kejiang Cao1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Jinsong Zhang1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Lianwen Qi1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Yan Chen1 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 2 Department of Emergency, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China ; 3 Emergency Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 4 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ; 5 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Nanjing Medical University · CNNanjing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the effects of various left anterior descending (LAD) artery-blocked sites on the development of acute myocardial infarction (AMI) and malignant arrhythmia in a swine model.

methodsTwenty-two pigs underwent occlusion of the coronary artery with balloon angioplasty were randomly divided into three groups according to the blocked site of the balloon: middle-site-blocked LAD group, bottom-third-blocked LAD group and control group. Then, the development of AMI and malignant arrhythmia, including ventricular tachycardia and ventricular fibrillation during the process of model creation, were recorded. Changes of the hemodynamics, blood gas analysis, electrocardiography, and myocardial enzymes were analyzed in each group before and after occlusion.

resultsMiddle-site-LAD blockage resulted in a larger infarction size and the corresponding incidence of ventricular fibrillation was significantly higher than that of the bottom-third-blocked group (P<0.05). After the occlusion, the QTc interval of the Middle-site-blocked LAD group was significantly longer than that in the other groups (P<0.01). Moreover, mean arterial blood pressure (MAP), left ventricular ejection fraction (LVEF), and partial pressure of oxygen (PaO2) were significantly lower, but partial pressure of carbon dioxide (PaCO2) increased, in the Middle-site-blocked-LAD group compared with that in the bottom-third-blocked group (P<0.01). Compared with the control group, the two LAD-blocked groups showed significantly higher levels of Mb, CK-MB, LDH, AST and cTnT (P<0.01) four hours after the artery occlusion. However, these indexes were not significantly different between the two LAD-blocked groups (P>0.05).

conclusionsLocation of LAD blockages in swine models may affect the development of AMI and malignant arrhythmia.

Indexed as

Acute myocardial infarction (AMI)left anterior descending (LAD)malignant arrhythmiaswine

Identifiers

PMID25276369
PMCPMC4178079
OpenAlexW2162545266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.