ArticleAnnals of thoracic medicine2014
Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis.
Article in Annals of thoracic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis.The Journal of infection · 2019Pooled it
- The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents.BMC infectious diseases · 2020Trial
- Differentiating pulmonary sarcoidosis from pulmonary tuberculosis in clinical practice: Insights from routine blood tests.Irish journal of medical science · 2026Article
- Composite Inflammatory Indices for the Differentiation of Tuberculosis, Sarcoidosis, and Reactive Lymphadenopathy in Patients Undergoing EBUS-TBNA.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2026Article
- The Prognostic Value of the Neutrophil-to-lymphocyte Ratio in Older Patients with Pulmonary Tuberculosis.Internal medicine (Tokyo, Japan) · 2026Article
- Association between neutrophil-lymphocyte ratio and latent tuberculosis infection in the United States: a cross-sectional study from NHANES 2011-2012.BMC infectious diseases · 2025Article
- Diagnostic accuracy of point-of-care triage tests for pulmonary tuberculosis using host blood protein biomarkers: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease.Pathogens (Basel, Switzerland) · 2025Article
- Neutrophil-to-lymphocyte ratio in community-acquired pneumonia: Diagnostic potential and its limitations in the COVID era.Journal of family medicine and primary care · 2024Article
- A Comparison Study of Lymph Node Tuberculosis and Sarcoidosis Involvement to Facilitate Differential Diagnosis and to Establish a Predictive Score for Tuberculosis.Pathogens (Basel, Switzerland) · 2024Article
- Can Complete Blood Count Parameters and Serum Electrolyte Levels Have a Predictive Role in Differential Diagnosis of Tuberculosis from Community-acquired Pneumonia in Children?Turkish archives of pediatrics · 2024Article
- Diagnostic Value of Imaging and Serological Biomarkers in Pulmonary Sarcoidosis.Advances in respiratory medicine · 2024Review
- Deciphering the significance of neutrophil to lymphocyte and monocyte to lymphocyte ratios in tuberculosis: A case-control study from southern India.F1000Research · 2024Article
- Association Between Indices of Peripheral Blood Inflammation and Cavitary Pulmonary Tuberculosis.International journal of general medicine · 2024Article
- Novel biomarkers for the assessment of disease activity in patients with sarcoidosis: a case-control study.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2023Article
- Systematic review of the diagnostic role of neutrophil to lymphocyte ratio in sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2023Article
- Accuracy of C-reactive protein and a differentiated white cell count in diagnosing tuberculosis.Southern African journal of infectious diseases · 2023Article
- Neutrophil-Lymphocyte Ratio and Monocyte-Lymphocyte Ratio According to the Radiologic Severity ofJournal of Korean medical science · 2022Article
- Difference between the blood samples of patients with bone and joint tuberculosis and patients with tuberculosis studied using machine learning.Frontiers in surgery · 2022Article
- Combination of prealbumin and tuberculosis-specific antigen/phytohemagglutinin ratio for discriminating active tuberculosis from latent tuberculosis infection.International journal of clinical practice · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe differential diagnosis of sarcoidosis creates a challange due to tuberculosis also having lung and lymph node involvement. Because both diseases show granulomatous inflammation, it may not be possible to distinguish tuberculosis and sarcoidosis in pathological specimens. As a result of the complexity in the differential diagnosis of sarcoidosis and tuberculosis, new markers for differentiation are being investigated.
objectiveThe aim of our study is to investigate the value of neutrophil/lymphocyte ratio (NLR) as a possible marker in differentiating sarcoidosis and tuberculosis. MATERIALS AND
methodsIn our study, 51 acid-fast bacilli (AFB) positive and/or culture-positive patients with pulmonary tuberculosis, 40 patients with biopsy-proven sarcoidosis and a control group consisting of 43 patients were included. In our study, information was collected retrospectively based on hospital records.
resultsLeukocyte and neutrophil counts, NLR, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) were significantly higher, and albumin was significantly lower in the tuberculosis group compared with sarcoidosis (for all parameters P < 0.001). The most appropriate cut-off value of NLR to distinguish tuberculosis from sarcoidosis was determined as 2.55. For this cut-off value of NLR there was 79% sensitivity, 69% specificity, 73% positive predictive value (PPV), 75% negative predictive value (NPV), and area under the curve (AUC) was 0.788. For differentiation of sarcoidosis from tuberculosis, accuracy of the NLR test according to this cut-off value was found as 76%.
conclusionNLR as a little known marker in respiratory medicine was found to be supportive in differentiation of tuberculosis and sarcoidosis. More studies on this issue is needed.
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