Evidence map›Paper›PMID 25276234›Full record

ArticleDiabetology & metabolic syndrome2014

Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus.

Zaid Al-Hamodi, Molham Al-Habori, Ali Al-Meeri, Riyadh Saif-Ali

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 3 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zaid Al-HamodiDepartment of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana'a, PO Box 19065, Sana'a, Republic of Yemen.
Molham Al-HaboriDepartment of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana'a, PO Box 19065, Sana'a, Republic of Yemen.
Ali Al-MeeriDepartment of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana'a, PO Box 19065, Sana'a, Republic of Yemen.
Riyadh Saif-AliDepartment of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana'a, PO Box 19065, Sana'a, Republic of Yemen.
Sana'a University · YE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlterations in plasma adipokines and/or inflammatory parameters in Type 2 DM remain vague as to whether they are due to obesity and/or directly associated with the diabetic state. Our objective was to compare plasma adiponectin, leptin, leptin/adiponectin ratio (LAR) and hs-CRP in obese non-diabetic subjects and non-obese Type 2 DM patients, as well as determining the association of these adipokines with MetS and diabetes-related quantitative traits.

methodsIn this study, 92 Yemeni male volunteers aged 25-60 years old were enrolled, 31 of whom were healthy subjects with BMI < 25 kg/m(2) served as control; 30 non-diabetic obese subjects BMI ≥ 30 kg/m(2) and FBG < 6.1 mmol/l; and 31 non-obese Type 2 DM with FBG > 7 mmol/l and BMI < 25 kg/m(2).

resultsAdiponectin was lower in obese subjects, with no differences between non-obese Type 2 DM patients and controls. In contrast, leptin, LAR and hs-CRP were higher in both obese subjects and non-obese Type 2 DM patients. Linear regression analysis showed adiponectin to be associated negatively with BMI, waist circumference, insulin, HOMA-β and HOMA-IR; whereas leptin, LAR and hs-CRP were associated positively with BMI, waist circumference, TG, FBG, insulin, HOMA-β and HOMA-IR. Moreover, adiponectin negatively correlated with leptin, LAR and hs-CRP; whereas leptin and LAR positively correlated with hs-CRP and with each other.

conclusionPlasma adiponectin is not affected by diabetes per se, suggesting that its alterations in Type 2 DM may be due to obesity and may be an important link between adiposity, IR and Type 2 DM.

Indexed as

Adiponectinhs-CRPLeptinLeptin/Adiponectin ratioObesityType 2 DM

Identifiers

PMID25276234
PMCPMC4177707
OpenAlexW2148667018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.