ArticleIranian journal of pharmaceutical research : IJPR2014
Progesterone and cilostazol protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide.
Article in Iranian journal of pharmaceutical research : IJPR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Protective effects of cilostazol against cisplatin-induced hepatorenal toxicity in male mice.Research in pharmaceutical sciences · 2026Article
- Crocin attenuates endoplasmic reticulum stress in methylglyoxal-induced diabetic nephropathy in male mice: MicroRNAs alterations and glyoxalase 1-Nrf2 signaling pathways.Iranian journal of basic medical sciences · 2022Article
- Cilostazol attenuates cardiac oxidative stress and inflammation in hypercholesterolemic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Possible mechanisms mediating the protective effect of cilostazol in L-arginine induced acute pancreatitis in rats: role of cGMP, cAMP, and HO-1.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis.Cell cycle (Georgetown, Tex.) · 2019Article
- Effects of a nutritional supplement in dogs affected by osteoarthritis.Veterinary medicine and science · 2019Article
- Effects of aging and menopause on pancreatic fat fraction in healthy women population: A strobe-compliant article.Medicine · 2019Article
- Co-culture of rat luteal cells with islet cells enhances islet viability and revascularization.In vitro cellular & developmental biology. Animal · 2018Article
- Polycystic ovarian syndrome is linked to increased oxidative stress in Omani women.International journal of women's health · 2018Article
- TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.Scientific reports · 2016Article
- Effects of Portulaca oleracea ethanolic extract on reproductive system of aging female mice.International journal of reproductive biomedicine · 2016Article
- Article
- Antidiabetic, hypolipidemic and hepatoprotective effects ofAvicenna journal of phytomedicineArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in-vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative stress in pancreatic isolated islets from mouse. Pancreatic islets were isolated from 84 male NMRI mice (25-30 g) by collagenase digestion method and pretreated for 48 h with cilostazol (10 μM), progesterone (0.5 μM) and glibenclamide (10 μM) in culture medium. Then islets were exposed to hydrogen peroxide (H2O2. 500 μM) for 2 h. Next, culture mediums containing glucose concentration of 2.8 mM or 16.7 mM were added to them and incubated in this status for 1 h. At the end, the rate of insulin output from islets, lipid peroxidation and antioxidant enzymes activities in islet tissues were assayed. Exposure of islets to H2O2, resulted in a significant decrease in insulin secretion, superoxide dismutase and catalase activities (P < 0.001). Also islets malondialdehyde levels were increased by H2O2, after addition of 2.8 mM (P < 0.05) and 16.7 mM (P < 0.001) glucose. 48 h pretreatment of islets with cilostazol and progesterone, significantly reverted back this changes (P < 0.05). Results of present study showed that cilostazol and progesterone protect mice pancreatic islets against H2O2-induced oxidative stress. At the end, our results suggested that protective effects of progesterone and cilostazol are mediated by augmentation the antioxidant defence system of islets.
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25276194PMC4177654W1897653258What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.