Evidence map›Paper›PMID 25275912›Full record

ReviewJournal of glaucoma

Animal models of exfoliation syndrome, now and future.

Simon W M John, Jeffrey M Harder, John H Fingert, Michael G Anderson

Abstract readReview
In one paragraph

Review in Journal of glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mitophagy: An Emerging Target in Ocular Pathology.Investigative ophthalmology & visual science · 2021
    Review
  5. Review
  6. Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simon W M John*The Howard Hughes Medical Institute †The Jackson Laboratory, Bar Harbor, ME ‡Department of Ophthalmology, Tufts University School of Medicine, Boston, MA Departments of §Ophthalmology and Visual Sciences ∥Molecular Physiology and Biophysics, University of Iowa ¶Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA.
Jeffrey M Harder
John H Fingert
Michael G Anderson

Funding

Factors Determining Intraocular Pressure and Glaucoma SusceptibilityR01EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 2002 to 2018
$12.4M
Genetic dissection of pigment dispersing iris diseaseR01EY017673 · NEI · UNIVERSITY OF IOWA · PI ANDERSON, MICHAEL G · 2008 to 2017
$3.1M
Howard Hughes Medical InstituteNEI NIH HHS R01 EY011721NEI NIH HHS R01 EY017673
6 · The paper itself

Abstract

At present, no animal models fully embody exfoliation syndrome or exfoliation glaucoma. Both genetic and environmental factors appear critical for disease manifestation, and both must be considered when generating animal models. Because mice provide a powerful mammalian platform for modeling complex disease, this paper focuses on mouse models of exfoliation syndrome and exfoliation glaucoma.

Indexed as

Disease Models, AnimalAnimalsExfoliation SyndromeGlaucoma, Open-AngleHumansMiceMice, KnockoutMice, Transgenic

Identifiers

PMID25275912
PMCPMC4383291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.