Evidence map›Paper›PMID 25275905›Full record

ReviewJournal of glaucoma

LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma.

Rozalia Laczko, Kornelia M Szauter, Katalin Csiszar

Open access · greenAbstract readReview
In one paragraph

Review in Journal of glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rozalia LaczkoJohn A. Burns School of Medicine, University of Hawaii, Honolulu, HI.
Kornelia M Szauter
Katalin Csiszar
University of Hawaiʻi at Mānoa · US

Funding

STEERING COMMITTEEU54MD008149 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI OFILI, ELIZABETH O. · 2012 to 2018
$21.1M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MOKUAU, NOREEN, SHIRAMIZU, BRUCE T · 2012 to 2018
$21.1M
THE NUTRIGENOMICS OF VITAMIN D METABOLISM IN AFRICAN-AMERICANSU54RR022762 · NCRR · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI NORRIS, KEITH C · 2007 to 2011
$19.6M
RESEARCH ETHICSU54RR026136 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI INAZU, JUDITH · 2010 to 2011
$8.5M
NCRR NIH HHS U54 RR022762NCRR NIH HHS U54RR022762NCRR NIH HHS U54 RR026136NCRR NIH HHS U54RR026136NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54 MD008149
6 · The paper itself

Abstract

Results of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.

Indexed as

Amino Acid OxidoreductasesEpithelial CellsEpithelial-Mesenchymal TransitionExfoliation SyndromeExtracellular MatrixGlaucoma, Open-AngleHumansAmino Acid OxidoreductasesLOXL1 protein, human

Identifiers

PMID25275905
PMCPMC4205763
OpenAlexW2041921669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.