ReviewCurrent opinion in HIV and AIDS2014
New insights into immune reconstitution inflammatory syndrome of the central nervous system.
Review in Current opinion in HIV and AIDS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- HIV Infection, Neurotoxicity, Inflammation, Premature Aging, and Therapeutic Challenges to PLWH: An Overview.International journal of molecular sciences · 2026Review
- Morbidity and mortality in tuberculosis associated immune reconstitution inflammatory syndrome in children living with HIV: A narrative review.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Article
- Meningeal Sporotrichosis Due toJournal of fungi (Basel, Switzerland) · 2022Article
- Central nervous system immune reconstitution inflammatory syndrome after autologous stem cell transplantation.Bone marrow transplantation · 2020Article
- Lateral amyotrophic sclerosis-like onset after combined antiretroviral treatment initiation.IDCases · 2020Article
- Co-occurrence of Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Anti-myelin Oligodendrocyte Glycoprotein Inflammatory Demyelinating Diseases: A Clinical Phenomenon to Be Taken Seriously.Frontiers in neurology · 2019Article
- Neurological syndromes driven by postinfectious processes or unrecognized persistent infections.Current opinion in neurology · 2018Review
- CNS immune reconstitution inflammatory syndrome.Handbook of clinical neurology · 2018Review
- Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy.The American journal of pathology · 2018Article
- The Role of Human Immunodeficiency Virus-Associated Vasculopathy in the Etiology of Stroke.The Journal of infectious diseases · 2017Article
- Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward KNeurobiology of disease · 2017Article
- HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.The Journal of biological chemistry · 2015Article
- Using the pathogenic and nonpathogenic nonhuman primate model for studying non-AIDS comorbidities.Current HIV/AIDS reports · 2015Review
- Neurologic Complications in Persons With HIV Infection in the Era of Antiretroviral Therapy.Topics in antiviral medicineArticle
- Infectious Agents and Stroke: A Systematic Review.Basic and clinical neuroscienceReview
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis in HIV Infection.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewTo highlight the importance of immune reconstitution inflammatory syndrome affecting the brain in HIV-infected individuals in the absence of opportunistic infections. To describe the varied clinical manifestations, unifying pathophysiological features and discuss the principles of management of this syndrome. RECENT
findingsImmune reconstitution inflammatory syndrome within the brain is commonly seen in patients with HIV infection upon initiation of antiretroviral drugs. The fulminant forms occur in the face of opportunistic infections or uncontrolled viral replication within the brain. In this case, the enhanced immune response is targeted against the microbial agent, and the brain suffers bystander damage. Treatment requires the combination of the antimicrobial agent, continued antiretrovirals and in some cases corticosteroids. It is increasingly being recognized that despite adequate control of viral replication in the brain, some patients develop a chronic form of T cell encephalitis which appears to be driven by continued production of HIV-Tat protein. In others, the immune response may be targeted against the host antigens in the brain. SUMMARY: In patients with central nervous system-immune reconstitution inflammatory syndrome, the use of corticosteroids and strategies that prevent T cell migration into the brain may be needed. Extreme caution is necessary if viral eradication strategies are to be employed that involve activation of viral reservoirs, as these patients may be at risk for developing central nervous system-immune reconstitution inflammatory syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.