ArticleCell death & disease2014
Severe influenza A(H1N1)pdm09 infection induces thymic atrophy through activating innate CD8(+)CD44(hi) T cells by upregulating IFN-γ.
Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- The Value of NLR, PLR, MLR, and SII Combined with Lower Respiratory Tract Symptoms in Predicting Pulmonary Complications in Non-Risk-Factor Influenza A Patients.International journal of general medicine · 2026Article
- Severe fever with thrombocytopenia syndrome virus infection induces thymic atrophy in IFNARVirulence · 2025Article
- A simple, rapid, and cost-effective model for predicting critical influenza a infection in children: a multicentre, retrospective cohort study.BMC pediatrics · 2025Article
- The thymus road to a T cell: migration, selection, and atrophy.Frontiers in immunology · 2024Review
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- Early peripheral blood lymphocyte subsets and cytokines in predicting the severity of influenza B virus pneumonia in children.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Development of a humanized HLA-A30 transgenic mouse model.Animal models and experimental medicine · 2022Article
- Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection.Frontiers in immunology · 2022Review
- Thymus, undernutrition, and infection: Approaching cellular and molecular interactions.Frontiers in nutrition · 2022Review
- A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection.Emerging microbes & infections · 2021Article
- Thymus Gland: A Double Edge Sword for Coronaviruses.Vaccines · 2021Review
- The Mechanism behind Influenza Virus Cytokine Storm.Viruses · 2021Review
- Recirculating IL-1R2Cellular & molecular immunology · 2021Article
- Infection-Associated Thymic Atrophy.Frontiers in immunology · 2021Review
- Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections.Frontiers in immunology · 2021Review
- Article
- Streptococcus suis Serotype 2 Infection Causes Host Immunomodulation through Induction of Thymic Atrophy.Infection and immunity · 2020Article
- When the Damage Is Done: Injury and Repair in Thymus Function.Frontiers in immunology · 2020Review
- T Cell Repertoire During Ontogeny and Characteristics in Inflammatory Disorders in Adults and Childhood.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymic atrophy has been described as a consequence of infection by several pathogens including highly pathogenic avian influenza virus and is induced through diverse mechanisms. However, whether influenza A(H1N1)pdm09 infection induces thymic atrophy and the mechanisms underlying this process have not been completely elucidated. Our results show that severe infection of influenza A(H1N1)pdm09 led to progressive thymic atrophy and CD4+ CD8+ double-positive (DP) T-cells depletion due to apoptosis. The viruses were present in thymus, where they activated thymic innate CD8(+)CD44(hi) single-positive (SP) thymocytes to secrete a large amount of IFN-γ. Milder thymic atrophy was observed in innate CD8+ T-cell-deficient mice (C57BL/6J). Neutralization of IFN-γ could significantly rescue the atrophy, but peramivir treatment did not significantly alleviate thymic atrophy. In this study, we demonstrated that thymic innate CD8(+)CD44(hi) SP T-cells have critical roles in influenza A(H1N1)pdm09 infection-induced thymic atrophy through secreting IFN-γ. This exceptional mechanism might serve as a target for the prevention and treatment of thymic atrophy induced by influenza A(H1N1)pdm09.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.