ArticleEpidemiology and infection2015
Public health measures to control the spread of antimicrobial resistance in Neisseria gonorrhoeae in men who have sex with men.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- A systematic review to identify research gaps in studies modeling MenB vaccinations against Neisseria infections.PloS one · 2025Pooled it
- Population-level mathematical modeling of antimicrobial resistance: a systematic review.BMC medicine · 2019Pooled it
- Self-Reported PrEP Use and Risk of Bacterial STIs Among Ontarian Men Who Are Gay or Bisexual or Have Sex With Men.Annals of family medicine · 2024Article
- Resistance-minimising strategies for introducing a novel antibiotic for gonorrhoea treatment: a mathematical modelling study.The Lancet. Microbe · 2023Article
- Resistance-minimizing strategies for introducing a novel antibiotic for gonorrhea treatment: a mathematical modeling study.medRxiv : the preprint server for health sciences · 2023Article
- Antibiotic treatment protocols revisited: the challenges of a conclusive assessment by mathematical modelling.Journal of the Royal Society, Interface · 2021Article
- Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Rise and fall of the new variant ofSexually transmitted infections · 2020Article
- Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England.Emerging infectious diseases · 2020Article
- Application of dynamic modelling techniques to the problem of antibacterial use and resistance: a scoping review.Epidemiology and infection · 2018Article
- An Illustration of the Potential Health and Economic Benefits of Combating Antibiotic-Resistant Gonorrhea.Sexually transmitted diseases · 2018Article
- Article
- Impact of Rapid Susceptibility Testing and Antibiotic Selection Strategy on the Emergence and Spread of Antibiotic Resistance in Gonorrhea.The Journal of infectious diseases · 2017Article
- Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies.PLoS computational biology · 2017Article
- Detection of antibiotic resistance is essential for gonorrhoea point-of-care testing: a mathematical modelling study.BMC medicine · 2017Article
- A comprehensive overview of urogenital, anorectal and oropharyngeal Neisseria gonorrhoeae testing and diagnoses among different STI care providers: a cross-sectional study.BMC infectious diseases · 2017Article
- Antibiotic-Resistant Neisseria gonorrhoeae Spread Faster with More Treatment, Not More Sexual Partners.PLoS pathogens · 2016Article
- Improving Control of Antibiotic-Resistant Gonorrhea by Integrating Research Agendas Across Disciplines: Key Questions Arising From Mathematical Modeling.The Journal of infectious diseases · 2016Review
- What is needed to guide testing for anorectal and pharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae in women and men? Evidence and opinion.BMC infectious diseases · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gonorrhoea is one of the most common sexually transmitted infections. The control of gonorrhoea is extremely challenging because of the repeated development of resistance to the antibiotics used for its treatment. We explored different strategies to control the spread of antimicrobial resistance and prevent increases in gonorrhoea prevalence. We used a mathematical model that describes gonorrhoea transmission among men who have sex with men and distinguishes gonorrhoea strains sensitive or resistant to three antibiotics. We investigated the impact of combination therapy, switching first-line antibiotics according to resistance thresholds, and other control efforts (reduced sexual risk behaviour, increased treatment rate). Combination therapy can delay the spread of resistance better than using the 5% resistance threshold. Increased treatment rates, expected to enhance gonorrhoea control, may reduce gonorrhoea prevalence only in the short term, but could lead to more resistance and higher prevalence in the long term. Re-treatment of resistant cases with alternative antibiotics can substantially delay the spread of resistance. In conclusion, combination therapy and re-treatment of resistant cases with alternative antibiotics could be the most effective strategies to prevent increases in gonorrhoea prevalence due to antimicrobial resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.