ArticleCerebral cortex (New York, N.Y. : 1991)2016
Synaptic Basis for Cross-modal Plasticity: Enhanced Supragranular Dendritic Spine Density in Anterior Ectosylvian Auditory Cortex of the Early Deaf Cat.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Brain Morphological Modifications in Congenital and Acquired Auditory Deprivation: A Systematic Review and Coordinate-Based Meta-Analysis.Frontiers in neuroscience · 2022Pooled it
- Regional gray matter thickness correlations of the hearing and deaf feline brains.Neuroimage. Reports · 2025Article
- Cortical thickness differences between hearing and perinatally deaf cats using ultra-high field MRI.Neuroimage. Reports · 2024Article
- Information encoded in volumes and areas of dendritic spines is nearly maximal across mammalian brains.Scientific reports · 2023Article
- The gradient in gray matter thickness across auditory cortex and differential cortical thickness changes following perinatal deafness.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Introduction: What Are Dendritic Spines?Advances in neurobiology · 2023Article
- Altered resting-state functional network connectivity in profound sensorineural hearing loss infants within an early sensitive period: A group ICA study.Human brain mapping · 2021Article
- Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.Frontiers in cellular neuroscience · 2021Article
- What is a multisensory cortex? A laminar, connectional, and functional study of a ferret temporal cortical multisensory area.The Journal of comparative neurology · 2020Article
- Spatial Cues Influence Time Estimations in Deaf Individuals.iScience · 2019Article
- Early Sensory Loss Alters the Dendritic Branching and Spine Density of Supragranular Pyramidal Neurons in Rodent Primary Sensory Cortices.Frontiers in neural circuits · 2019Article
- Somatosensory Cross-Modal Reorganization in Children With Cochlear Implants.Frontiers in neuroscience · 2019Article
- Compensatory Plasticity in the Lateral Extrastriate Visual Cortex Preserves Audiovisual Temporal Processing following Adult-Onset Hearing Loss.Neural plasticity · 2019Article
- Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices.Brain structure & function · 2018Article
- Is territorial expansion a mechanism for crossmodal plasticity?The European journal of neuroscience · 2017Article
- Visually Evoked Visual-Auditory Changes Associated with Auditory Performance in Children with Cochlear Implants.Frontiers in human neuroscience · 2017Article
- Cortical and thalamic connectivity of the auditory anterior ectosylvian cortex of early-deaf cats: Implications for neural mechanisms of crossmodal plasticity.Hearing research · 2016Article
- The onset of visual experience gates auditory cortex critical periods.Nature communications · 2016Article
- The Right Hemisphere Planum Temporale Supports Enhanced Visual Motion Detection Ability in Deaf People: Evidence from Cortical Thickness.Neural plasticity · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In the cat, the auditory field of the anterior ectosylvian sulcus (FAES) is sensitive to auditory cues and its deactivation leads to orienting deficits toward acoustic, but not visual, stimuli. However, in early deaf cats, FAES activity shifts to the visual modality and its deactivation blocks orienting toward visual stimuli. Thus, as in other auditory cortices, hearing loss leads to cross-modal plasticity in the FAES. However, the synaptic basis for cross-modal plasticity is unknown. Therefore, the present study examined the effect of early deafness on the density, distribution, and size of dendritic spines in the FAES. Young cats were ototoxically deafened and raised until adulthood when they (and hearing controls) were euthanized, the cortex stained using Golgi-Cox, and FAES neurons examined using light microscopy. FAES dendritic spine density averaged 0.85 spines/μm in hearing animals, but was significantly higher (0.95 spines/μm) in the early deaf. Size distributions and increased spine density were evident specifically on apical dendrites of supragranular neurons. In separate tracer experiments, cross-modal cortical projections were shown to terminate predominantly within the supragranular layers of the FAES. This distributional correspondence between projection terminals and dendritic spine changes indicates that cross-modal plasticity is synaptically based within the supragranular layers of the early deaf FAES.
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Registered trials
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