ArticleNucleic acids research2014
A dsRNA-binding protein of a complex invertebrate DNA virus suppresses the Drosophila RNAi response.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Host serum-circulating flavivirus NS1 co-opts mosquito miRNA processing to suppress early immune defense.Nature communications · 2026Article
- RNA Interference Applied to Crustacean Aquaculture.Biomolecules · 2024Review
- RNAi-Based Therapy: Combating Shrimp Viral Diseases.Viruses · 2023Review
- Infection Defects of RNA and DNA Viruses Induced by Antiviral RNA Interference.Microbiology and molecular biology reviews : MMBR · 2023Review
- Induction of Multiple Immune Signaling Pathways inViruses · 2022Article
- BmNPV p35 Reduces the Accumulation of Virus-Derived siRNAs and Hinders the Function of siRNAs to Facilitate Viral Infection.Frontiers in immunology · 2022Article
- Antiviral RNA interference in disease vector (Asian longhorned) ticks.PLoS pathogens · 2021Article
- The discovery, distribution, and diversity of DNA viruses associated withVirus evolution · 2021Article
- A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Inhibition of dicer activity in lepidopteran and dipteran cells by baculovirus-mediated expression of Flock House virus B2.Scientific reports · 2019Article
- IIV-6 Inhibits NF-κB Responses inViruses · 2019Article
- Induction and Suppression of NF-κB Signalling by a DNA Virus ofJournal of virology · 2019Article
- The effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytes.Archives animal breeding · 2019Article
- RNA interference-based antiviral immune response against the salivary gland hypertrophy virus in Glossina pallidipes.BMC microbiology · 2018Article
- Isolation of a natural DNA virus of Drosophila melanogaster, and characterisation of host resistance and immune responses.PLoS pathogens · 2018Article
- RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates.Genetics · 2018Article
- Review
- Review
- The Ambystoma tigrinum virus (ATV) RNase III gene can modulate host PKR activation and interferon production.Virology · 2017Article
- Innate and intrinsic antiviral immunity in Drosophila.Cellular and molecular life sciences : CMLS · 2017Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invertebrate RNA viruses are targets of the host RNA interference (RNAi) pathway, which limits virus infection by degrading viral RNA substrates. Several insect RNA viruses encode suppressor proteins to counteract this antiviral response. We recently demonstrated that the dsDNA virus Invertebrate iridescent virus 6 (IIV-6) induces an RNAi response in Drosophila. Here, we show that RNAi is suppressed in IIV-6-infected cells and we mapped RNAi suppressor activity to the viral protein 340R. Using biochemical assays, we reveal that 340R binds long dsRNA and prevents Dicer-2-mediated processing of long dsRNA into small interfering RNAs (siRNAs). We demonstrate that 340R additionally binds siRNAs and inhibits siRNA loading into the RNA-induced silencing complex. Finally, we show that 340R is able to rescue a Flock House virus replicon that lacks its viral suppressor of RNAi. Together, our findings indicate that, in analogy to RNA viruses, DNA viruses antagonize the antiviral RNAi response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.