ArticleCurrent Alzheimer research2014
Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment.
Article in Current Alzheimer research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Functional Disability in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Neuropsychology review · 2016Pooled it
- Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech.Current Alzheimer research · 2015Trial
- Uncovering pathology, subjective cognitive complaints, and sex in early Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Subjective cognitive complaints and future risk of dementia and cognitive impairment, which matters most.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2025Article
- Distinct composition of different types of Abeta plaques in the pathogenesis of Alzheimer's disease and the role of neutrophil-derived myeloperoxidase.Molecular brain · 2025Article
- Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis.JAMA network open · 2025Observational
- Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry.Alzheimer's research & therapy · 2025Article
- A short version of the Everyday Cognition scale can predict clinical progression and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Validation of the Short Form of Korean-Everyday Cognition (K-ECog).Journal of Korean medical science · 2023Article
- Observational
- Associations of the Harvard Automated Phone Task and Alzheimer's Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings.Journal of Alzheimer's disease : JAD · 2023Article
- Focal-type, but not Diffuse-type, Amyloid Beta Plaques are Correlated with Alzheimer's Neuropathology, Cognitive Dysfunction, and Neuroinflammation in the Human Hippocampus.Neuroscience bulletin · 2022Article
- The role of dyadic cognitive report and subjective cognitive decline in early ADRD clinical research and trials: Current knowledge, gaps, and recommendations.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Measurement of Subjective Cognitive Decline (SCD) Using Korean-Everyday Cognition (K-ECog) as a Screening Tool: a Feasibility Study.Dementia and neurocognitive disorders · 2021Article
- Mindful walking and cognition in older adults: A proof of concept study using in-lab and ambulatory cognitive measures.Preventive medicine reports · 2021Article
- Individual Differences and Features of Self-reported Memory Lapses as Risk Factors for Alzheimer Disease Among Adults Aged 50 Years and Older: Protocol for a Coordinated Analysis Across Two Longitudinal Data Sets.JMIR research protocols · 2021Article
- Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum.Alzheimer's research & therapy · 2020Article
- Validation of online functional measures in cognitively impaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Observational
- Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundImpairment in instrumental activities of daily living (IADL) starts as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. However, most IADL scales have not shown IADL alterations in clinically normal (CN) elderly. The objective of this study was to determine which of the IADL-related Everyday Cognition (ECog) scale items are most sensitive for detection of early functional changes.
methodsWe assessed 290 CN and 495 MCI participants from the Alzheimer's Disease Neuroimaging Initiative. We performed logistic regression analyses predicting the probability of CN vs. MCI diagnosis using only the 17 participant-based and 17 informant-based ECog items related to IADL. We then performed Cox regression analyses to predict progression from CN to MCI. All analyses were adjusted for demographic characteristics.
resultsWe found that worse performance on "remembering a few shopping items" (participant and informant-based p<0.0001), "remembering appointments" (participant and informant-based p<0.0001), "developing a schedule in advance of anticipated events" (participant-based p=0.007), "balancing checkbook" (participant-based p=0.02), and "keeping mail and papers organized" (informant-based p=0.002) best discriminated MCI from CN. We found that worse performance on "keeping mail and papers organized" (participant-based Hazard Ratio (HR)=2.27, p=0.07) marginally predicted greater hazard of progressing from CN to MCI.
conclusionsOur results indicate that a few simple questions targeting early functional changes, addressed either to the individual or informant, can effectively distinguish between CN elderly and individuals with MCI. Additionally, one of the above questions related to organization suggested which CN individuals are likely to progress to MCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.