ArticleEpidemiology and infection2015
Vitamin D status and incidence of tuberculosis infection conversion in contacts of pulmonary tuberculosis patients: a prospective cohort study.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 8 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 8 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Association of variant vitamin statuses and tuberculosis development: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- Diabetes mellitus and latent tuberculosis infection: an updated meta-analysis and systematic review.BMC infectious diseases · 2023Pooled it
- Vitamin D and the risk of latent tuberculosis infection: a systematic review and meta-analysis.BMC pulmonary medicine · 2022Pooled it
- The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Drivers of Seasonal Variation in Tuberculosis Incidence: Insights from a Systematic Review and Mathematical Model.Epidemiology (Cambridge, Mass.) · 2018Pooled it
- Diabetes Mellitus and Latent Tuberculosis Infection: A Systematic Review and Metaanalysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Vitamin D deficiency and the risk of tuberculosis: a meta-analysis.Drug design, development and therapy · 2017Pooled it
- Vitamin D deficiency is associated with the severity of COPD: a systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2015Pooled it
- Efficacy of vitamin DTrials · 2017Trial
- Latent tuberculosis in children and youth with type 1 diabetes mellitus in Dar es Salaam, Tanzania: a cross section survey.BMC infectious diseases · 2023Article
- Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study.Cureus · 2023Article
- Increased Risk of Incident Diabetes Among Individuals With Latent Tuberculosis Infection.Diabetes care · 2022Article
- A scoping review on climate change and tuberculosis.International journal of biometeorology · 2021Article
- Association of genetic variations in the vitamin D pathway with susceptibility to tuberculosis in Kazakhstan.Molecular biology reports · 2020Article
- Levels of vitamin D-associated cytokines distinguish between active and latent tuberculosis following a tuberculosis outbreak.BMC infectious diseases · 2019Article
- Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011-2012.Infection and drug resistance · 2019Article
- Vitamin D₃ Status and the Association with Human Cathelicidin Expression in Patients with Different Clinical Forms of Active Tuberculosis.Nutrients · 2018Article
- Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners.Scientific reports · 2018Article
- Impact of Childhood Malnutrition on Host Defense and Infection.Clinical microbiology reviews · 2017Review
- Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012. Initially, the participants were negative to latent TB infection after a screening that included TST and QFT-GIT tests, and other examinations. A baseline determination of 25-hydroxyvitamin D [25(OH)D] was obtained by chemiluminescence immunoassay. After 8-10 weeks, participants were screened for a second time to determine TB infection conversion (TBIC). Poisson regression models were used in the statistical analysis. Of the 247 participants in the cohort, 198 (80·2%) were screened twice and 18 (9·1%) were TBIC cases. The means of VitD concentration in the TBIC cases and the non-cases were 20·7±11·9 and 27·2±11·4 ng/ml (P = 0·028), respectively. Adjusted for high exposure and TB sputum acid-fast bacilli (AFB)-positive index case, higher serum VitD concentration was associated with low incidence of TBIC (P trend = 0·005), and an increase of 1 ng/ml VitD concentration decreased the incidence of TBIC by 6% (relative risk 0·94, 95% confidence interval 0·90-0·99, P = 0·015). The results suggest that sufficient VitD level could be a protective factor of TBIC.
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