Evidence map›Paper›PMID 25273917›Full record

ArticleMagnetic resonance in medicine2015

Magnetic resonance imaging of ionic currents in solution: the effect of magnetohydrodynamic flow.

Mukund Balasubramanian, Robert V Mulkern, William M Wells, Padmavathi Sundaram, Darren B Orbach

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Can MRI Be Used as a Sensor to Record Neural Activity?Sensors (Basel, Switzerland) · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mukund BalasubramanianDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Robert V MulkernDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
William M WellsDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Padmavathi SundaramDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Darren B OrbachDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI PUJOL, SONIA · 2012 to 2022
$20.9M
Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
Encephalographic MRI and Epilepsy Discharge LocalizationR21NS076859 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ORBACH, DARREN BENJAMIN · 2011 to 2012
$519k
NIBIB NIH HHS P41 EB015898NIBIB NIH HHS P41EB015898NIBIB NIH HHS P41 EB015902NIBIB NIH HHS P41EB015902NINDS NIH HHS R21 NS076859NINDS NIH HHS R21NS076859
6 · The paper itself

Abstract

purposeReliably detecting MRI signals in the brain that are more tightly coupled to neural activity than blood-oxygen-level-dependent fMRI signals could not only prove valuable for basic scientific research but could also enhance clinical applications such as epilepsy presurgical mapping. This endeavor will likely benefit from an improved understanding of the behavior of ionic currents, the mediators of neural activity, in the presence of the strong magnetic fields that are typical of modern-day MRI scanners. THEORY: Of the various mechanisms that have been proposed to explain the behavior of ionic volume currents in a magnetic field, only one-magnetohydrodynamic flow-predicts a slow evolution of signals, on the order of a minute for normal saline in a typical MRI scanner.

methodsThis prediction was tested by scanning a volume-current phantom containing normal saline with gradient-echo-planar imaging at 3 T.

resultsGreater signal changes were observed in the phase of the images than in the magnitude, with the changes evolving on the order of a minute.

conclusionThese results provide experimental support for the MHD flow hypothesis. Furthermore, MHD-driven cerebrospinal fluid flow could provide a novel fMRI contrast mechanism.

Indexed as

Magnetic FieldsBrainCerebrospinal FluidHumansHydrodynamicsIonsMagnetic Resonance ImagingOxygenPhantoms, ImagingIonsOxygenBOLDCSFfMRIionic currentsmagnetohydrodynamic flowneuronal currents

Identifiers

PMID25273917
PMCPMC4382464

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.