ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration.JOR spine · 2025Article
- Annulus Fibrosus Repair via Interpenetration of a Non-Woven Scaffold Supports Tissue Integration and Prevents Re-Herniation.JOR spine · 2025Article
- Injectable Radiopaque Hyaluronic Acid Granular Hydrogels for Intervertebral Disc Repair.Advanced healthcare materials · 2024Article
- INTERVERTEBRAL DISC DEGENERATION INSTIGATES VERTEBRAL ENDPLATE REMODELING AND FACET JOINT PATHOLOGY IN A LARGE ANIMAL MODEL.European cells & materials · 2024Article
- Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model.JOR spine · 2023Article
- Tension-activated nanofiber patches delivering an anti-inflammatory drug improve repair in a goat intervertebral disc herniation model.Science translational medicine · 2023Article
- Different responses of cervical intervertebral disc caused by low and high virulence bacterial infection: a comparative study in rats.Bioengineered · 2022Article
- Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model.Arthritis research & therapy · 2021Article
- In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.Clinical biomechanics (Bristol, Avon) · 2021Article
- Degeneration alters structure-function relationships at multiple length-scales and across interfaces in human intervertebral discs.Journal of anatomy · 2021Article
- Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate-Severity Disc Degeneration in Goats.Tissue engineering. Part A · 2021Article
- Restoration of physiologic loading modulates engineered intervertebral disc structure and function in an in vivo model.JOR spine · 2020Article
- Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model.Osteoarthritis and cartilage · 2019Article
- Effect of diminished flow in rabbit lumbar arteries on intervertebral disc matrix changes using MRI T2-mapping and histology.BMC musculoskeletal disorders · 2019Article
- Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc.Science translational medicine · 2018Article
- Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Towards the scale up of tissue engineered intervertebral discs for clinical application.Acta biomaterialia · 2018Article
- In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty.Scientific reports · 2017Article
- Multimodal quantitative magnetic resonance imaging for lumbar intervertebral disc degeneration.Experimental and therapeutic medicine · 2017Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Magnetic resonance imaging (MRI) with T2-weighting is routinely performed to assess intervertebral disc degeneration. Standard clinical evaluations of MR images are qualitative, however, and do not focus on region-specific alterations in the disc. Utilizing a rabbit needle puncture model, T2 mapping was performed on injured discs to develop a quantitative description of the degenerative process following puncture. To do so, an 18G needle was inserted into four discs per rabbit (L3/L4 to L6/L7) and T2 maps were generated pre- and 4 weeks post-injury. Individual T2 maps were normalized to a disc-specific coordinate system and then averaged for pre- and post-injury population composite T2 maps. We also developed a method to automatically segment the nucleus pulposus by fitting the NP region of the T2 maps with modified 2-D and 3-D Gaussian distribution functions. Puncture injury produced alterations in MR signal intensity in a region-specific manner mirroring human degeneration. Population average T2 maps provided a quantitative representation of the injury response, and identified deviations of individual degenerate discs from the pre-injury population. We found that the response to standardized injury was modest at lower lumbar levels, likely as a result of increased disc dimensions. These tools will be valuable for the quantitative characterization of disc degeneration in future clinical and pre-clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.