ArticleHernia : the journal of hernias and abdominal wall surgery2015
Bioengineered acellular dermal matrices for the repair of abdominal wall defects in rats.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Pooled it
- Clinical outcomes of xenogeneic acellular dermal matrix combined with full-thickness skin graft in the eyelid reconstruction following the excision of eyelid malignant tumors.Frontiers in oncology · 2025Article
- Decellularization of Skin Tissue.Advances in experimental medicine and biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcellular grafts can be used as a better substitute for the prosthetic meshes in reconstruction of abdominal wall defect. The purpose of study was to develop bioengineered scaffolds by seeding primary mouse embryo fibroblast cells (p-MEF) on decellularized rabbit skin and to test the efficacy of these scaffolds for the repair of abdominal wall defects in rats.
methodsThe study was conducted on 18 clinically healthy adult Wistar rats of either sex. The animals were randomly divided into two equal groups having nine animals in each group. In both the groups a 20 × 20 mm(2) size full thickness muscle defect was created under xylazine and ketamine anaesthesia in the mid-ventral abdominal wall. In group I the defect was repaired with acellular dermal matrix alone and in group II it was repaired with p-MEF seeded dermal matrix. Matrices were implanted by synthetic absorbable suture material (polyglycolic acid) in continuous suture pattern. The efficacy of the bioengineered matrices in the reconstruction of full thickness abdominal wall defects was evaluated.
resultsMacroscopic observations revealed that adhesions with skin and abdominal viscera were found to be less in group II as compared to group I. Immunological reactions were reduced in group II. Histopathological observations also revealed that fibroplasia and collagen fiber arrangement was found to be better in group II. No recurrence of hernia was found in both the groups.
conclusionOn the basis of the results bioengineered cell seeded scaffolds were found to be better than non-cell seeded scaffolds for the repair of abdominal wall defects in rats.
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