ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2014
Biomarkers and clinical staging in psychiatry.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 7 syntheses or guidelines pooled it, 309 citations in OpenAlex.
- Pooled it
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- A systematic review and meta-analysis of sleep and circadian rhythms disturbances in individuals at high-risk of developing or with early onset of bipolar disorders.Neuroscience and biobehavioral reviews · 2022Pooled it
- Idiopathic and acquired pedophilia as two distinct disorders: an insight from neuroimaging.Brain imaging and behavior · 2021Pooled it
- Structural alterations in functional neurological disorder and related conditions: a software and hardware problem?NeuroImage. Clinical · 2019Pooled it
- Autism spectrum disorders: a meta-analysis of executive function.Molecular psychiatry · 2018Pooled it
- White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids.BMC psychiatry · 2016Pooled it
- Sleep disruption and its psychological treatment in young people at risk of psychosis: A peer methods qualitative evaluation.The British journal of clinical psychology · 2026Trial
- Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome.Journal of psychiatric research · 2021Trial
- A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder.BMC psychiatry · 2019Trial
- Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks.Dialogues in clinical neuroscience · 2026Review
- Why psychopathology research should avoid studying one mental disorder at a time: An intergenerational and developmental evidence base for understanding "p".Journal of psychopathology and clinical science · 2026Review
- Perturbations of whole-brain model reveal critical areas related to relapse of early psychosis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Protein Kinase Expression of the AKT/mTOR Signaling Pathway in Peripheral Mononuclear Cells of Schizophrenia Patients: A Pilot Study.NeuroSci · 2025Article
- Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study.Psychological medicine · 2025Article
- A Phenomenological Reappraisal of Dynamical Systems in Psychopathology.Psychopathology · 2025Review
- Substance use disorders: a call for a staging paradigm.Translational psychiatry · 2025Review
- A Dual Biomarker Approach to Stress: Hair and Salivary Cortisol Measurement in Students via LC-MS/MS.Analytical science advances · 2025Article
- Relapse prediction using wearable data through convolutional autoencoders and clustering for patients with psychotic disorders.Scientific reports · 2025Article
- Towards person-centered care in global mental health: implications for meta-analyses and clinical trials.Epidemiology and psychiatric sciences · 2025Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Personalized medicine is rapidly becoming a reality in today's physical medicine. However, as yet this is largely an aspirational goal in psychiatry, despite significant advances in our understanding of the biochemical, genetic and neurobiological processes underlying major mental disorders. Preventive medicine relies on the availability of predictive tools; in psychiatry we still largely lack these. Furthermore, our current diagnostic systems, with their focus on well-established, largely chronic illness, do not support a pre-emptive, let alone a preventive, approach, since it is during the early stages of a disorder that interventions have the potential to offer the greatest benefit. Here, we present a clinical staging model for severe mental disorders and discuss examples of biological markers that have already undergone some systematic evaluation and that could be integrated into such a framework. The advantage of this model is that it explicitly considers the evolution of psychopathology during the development of a mental illness and emphasizes that progression of illness is by no means inevitable, but can be altered by providing appropriate interventions that target individual modifiable risk and protective factors. The specific goals of therapeutic intervention are therefore broadened to include the prevention of illness onset or progression, and to minimize the risk of harm associated with more complex treatment regimens. The staging model also facilitates the integration of new data on the biological, social and environmental factors that influence mental illness into our clinical and diagnostic infrastructure, which will provide a major step forward in the development of a truly pre-emptive psychiatry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.