ArticleDevelopment (Cambridge, England)2014
Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- The cardiac conduction system: development, function and therapeutic targets.Nature reviews. Cardiology · 2026Review
- GPAT4 sustains endoplasmic reticulum homeostasis in endocardial cells and safeguards heart development.Nature communications · 2025Article
- Molecular Pathways and Animal Models of Ebstein's Anomaly.Advances in experimental medicine and biology · 2024Review
- Endocardial Regulation of Cardiac Development.Journal of cardiovascular development and disease · 2022Review
- Endocardial-Myocardial Interactions During Early Cardiac Differentiation and Trabeculation.Frontiers in cardiovascular medicine · 2022Review
- Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration.Expert opinion on therapeutic targets · 2021Review
- Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart.American journal of physiology. Heart and circulatory physiology · 2021Article
- Graphene Electric Field Sensor Enables Single Shot Label-Free Imaging of Bioelectric Potentials.Nano letters · 2021Article
- Adherens junction engagement regulates functional patterning of the cardiac pacemaker cell lineage.Developmental cell · 2021Article
- Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis.Journal of cardiovascular development and disease · 2021Review
- The Endocardium and Heart Valves.Cold Spring Harbor perspectives in biology · 2020Review
- Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome.Cell stem cell · 2020Article
- Simplified platform for mosaic in vivo analysis of cellular maturation in the developing heart.Scientific reports · 2019Article
- Microinjection-based System for In Vivo Implantation of Embryonic Cardiomyocytes in the Avian Embryo.Journal of visualized experiments : JoVE · 2019Article
- Article
- Transcriptional regulation of the cardiac conduction system.Nature reviews. Cardiology · 2018Review
- Optical Electrophysiology in the Developing Heart.Journal of cardiovascular development and disease · 2018Review
- Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.Nature protocols · 2018Article
- Development and Function of the Cardiac Conduction System in Health and Disease.Journal of cardiovascular development and disease · 2017Article
- Volumetric optical mapping in early embryonic hearts using light-sheet microscopy.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Efficient blood flow depends on two developmental processes that occur within the atrioventricular junction (AVJ) of the heart: conduction delay, which entrains sequential chamber contraction; and valve formation, which prevents retrograde fluid movement. Defects in either result in severe congenital heart disease; however, little is known about the interplay between these two crucial developmental processes. Here, we show that AVJ conduction delay is locally assigned by the morphogenetic events that initiate valve formation. Our data demonstrate that physical separation from endocardial-derived factors prevents AVJ myocardium from becoming fast conducting. Mechanistically, this physical separation is induced by myocardial-derived factors that support cardiac jelly deposition at the onset of valve formation. These data offer a novel paradigm for conduction patterning, whereby reciprocal myocardial-endocardial interactions coordinate the processes of valve formation with establishment of conduction delay. This, in turn, synchronizes the electrophysiological and structural events necessary for the optimization of blood flow through the developing heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.