Evidence map›Paper›PMID 25273081›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

Progress toward curing HIV infections with hematopoietic stem cell transplantation.

Stephen T Smiley, Anjali Singh, Sarah W Read, Opendra K Sharma, Diana Finzi, Clifford Lane, Jeffrey S Rice

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. HIV Reservoirs and Treatment Strategies toward Curing HIV Infection.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Highlights from the 24Journal of virus eradication · 2017
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephen T SmileyDivision of AIDS.
Anjali SinghDivision of AIDS.
Sarah W ReadDivision of AIDS.
Opendra K SharmaDivision of AIDS.
Diana FinziDivision of AIDS.
Clifford LaneClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation.
Jeffrey S RiceDivision of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
AIDS United · USNational Institute of Allergy and Infectious Diseases · US

Funding

Pathogenesis and Treatment of HIV InfectionZIAAI000585 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LANE, CLIFFORD · 2009 to 2025
$26.8M
6 · The paper itself

Abstract

Combination antiretroviral therapy can suppress human immunodeficiency virus (HIV) infection but cannot completely eradicate the virus. A major obstacle in the quest for a cure is the difficulty in targeting and measuring latently infected cells. To date, a single person seems to have been cured of HIV. Hematopoietic stem cell transplantation (HSCT) preceded this cancer patient's long-term sustained HIV remission, but researchers have been unable to replicate this cure, and the mechanisms that led to HIV remission remain to be established. In February 2014, the National Institute of Allergy and Infectious Diseases sponsored a workshop that provided a venue for in-depth discussion of whether HSCT could be exploited to cure HIV in cancer patients requiring such procedures. Participants also discussed how HSCT might be applied to a broader community of HIV-infected persons in whom the risks of HSCT currently outweigh the likelihood and benefits of HIV cure.

Indexed as

Biomedical ResearchHematopoietic Stem Cell TransplantationHIV InfectionsHumansHIVlatencyreservoirstransplantation

Identifiers

PMID25273081
PMCPMC4296106
OpenAlexW2125910823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.