Evidence map›Paper›PMID 25272992›Full record

ArticleParticle and fibre toxicology2014

Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study.

Andrea A Baccarelli, Yinan Zheng, Xiao Zhang, Dou Chang, Lei Liu, Katherine Rose Wolf, Zhou Zhang, John P McCracken, Anaité Díaz, Pier Alberto Bertazzi and 5 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Particle and fibre toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Environmental and Occupational Short-Term Exposure to Airborne Particles and FEVInternational journal of environmental research and public health · 2021
    Pooled it
  2. Trial
  3. Pilot study of a community-based PMBMC public health · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Air Pollution-Related Neurotoxicity Across the Life Span.Annual review of pharmacology and toxicology · 2023
    Review
  9. PMJournal of public health research · 2023
    Article
  10. Article
  11. Ambient Air Pollution and Socioeconomic Status in China.Environmental health perspectives · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Andrea A BaccarelliDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA. abaccare@hsph.harvard.edu.
Yinan ZhengInstitute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. y-zheng@northwestern.edu.
Xiao ZhangDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. xiao-zhang@northwestern.edu.
Dou ChangDepartment of Safety Engineering, China Institute of Industrial Health, Beijing, China. changdou2004@sohu.com.
Lei LiuDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. lei.liu@northwestern.edu.
Katherine Rose WolfDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. wolf@northwestern.edu.
Zhou ZhangDriskill Graduate Program in Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. zhou.zhang@northwestern.edu.
John P McCrackenDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA. jmccrack@hsph.harvard.edu.
Anaité DíazCenter for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala. adiaz@ces.uvg.edu.gt.
Pier Alberto BertazziCenter of Molecular and Genetic Epidemiology, Department of Clinical Sciences and Community Health, University of Milan and IRCCS Foundation Ca' Granda, Ospedale Maggiore Policlinico, Italy. pieralberto.bertazzi@unimi.it.
Joel SchwartzDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA. jschwrtz@hsph.harvard.edu.
Sheng WangDepartment of Occupational and Environmental Health, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing, 100191, China. shengw@bjmu.edu.cn.
Choong-Min KangDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA. cmkang@hsph.harvard.edu.
Petros KoutrakisDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA. petros@hsph.harvard.edu.
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. l-hou@northwestern.edu.
Northwestern University · USPeking University · CNUniversidad del Valle de Guatemala · GTUniversity of Milan · IT

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4M
Histone modifications and respiratory effects of traffic particle exposureR21ES020984 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2013
$455k
Micro-RNA Profiling and Cardiovascular Effects of Traffic Particle ExposureR21ES020010 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACCARELLI, ANDREA, HOU, LIFANG · 2011 to 2012
$443k
NIEHS NIH HHS 1R21ES020010NIEHS NIH HHS ES000002NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R01ES021733NIEHS NIH HHS R21 ES020010NIEHS NIH HHS R21 ES020984NIEHS NIH HHS R21ES020984
6 · The paper itself

Abstract

backgroundExposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to respiratory effects remains under-investigated. We evaluated the effects of traffic-related PM(2.5) and its elemental components on lung function in two highly exposed groups of healthy adults in Beijing, China.

methodsThe Beijing Truck Driver Air Pollution Study (BTDAS) included 60 truck drivers and 60 office workers evaluated in 2008. On two days separated by 1-2 weeks, we measured lung function at the end of the work day, personal PM(2.5), and nine elemental components of PM(2.5) during eight hours of work, i.e., elemental carbon (EC), potassium (K), sulfur (S), iron (Fe), silicon (Si), aluminum (Al), zinc (Zn), calcium (Ca), and titanium (Ti). We used covariate-adjusted mixed-effects models including PM(2.5) as a covariate to estimate the percentage change in lung function associated with an inter-quartile range (IQR) exposure increase.

resultsThe two groups had high and overlapping exposure distributions with mean personal PM(2.5) of 94.6 μg/m³ (IQR: 48.5-126.6) in office workers and 126.8 μg/m³ (IQR: 73.9-160.5) in truck drivers. The distributions of the nine elements showed group-specific profiles and generally higher levels in truck drivers. In all subjects combined, forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) did not significantly correlate with PM(2.5). However, FEV1 showed negative associations with concentrations of four elements: Si (-3.07%, 95% CI: -5.00; -1.11, IQR: 1.54), Al (-2.88%, 95% CI: -4.91; -0.81, IQR: 0.86), Ca (-1.86%, 95% CI: -2.95; -0.76, IQR: 1.33), and Ti (-2.58%, 95% CI: -4.44; -0.68, IQR: 0.03), and FVC showed negative associations with concentrations of three elements: Si (-3.23%, 95% CI: -5.61; -0.79), Al (-3.26%, 95% CI: -5.73; -0.72), and Ca (-1.86%, 95% CI: -3.23; -0.47). In stratified analysis, Si, Al, Ca, and Ti showed associations with lung function only among truck drivers, and no significant association among office workers.

conclusionSelected elemental components of PM(2.5) showed effects on lung function that were not found in analyses of particle levels alone.

Indexed as

Urban HealthAdultAir PollutionAluminumCalciumChinaEnvironmental IllnessFemaleForced Expiratory VolumeHumansInhalation ExposureLungLung DiseasesMaleOccupationsParticulate MatterAluminumCalciumParticulate MatterSiliconTitaniumVehicle Emissions

Identifiers

PMID25272992
PMCPMC4192276
OpenAlexW2111127953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.