ArticleInternational journal of molecular sciences2014
The beneficial effects of combined grape pomace and omija fruit extracts on hyperglycemia, adiposity and hepatic steatosis in db/db mice: a comparison with major index compounds.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The high-value and sustainable utilization of grape pomace: A review.Food chemistry: X · 2024Review
- Exploring the Antihyperglycemic Chemical Composition and Mechanisms of Tea Using Molecular Docking.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Hypoglycemic effects of esculeoside A are mediated via activation of AMPK and upregulation of IRS-1.BMC complementary and alternative medicine · 2019Article
- Low-dose grape pomace and omija fruit extract is more effective than high-dose in lowering oxidative stress and fat-pad mass inFood science and biotechnology · 2017Article
- Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice.Nutrition research and practice · 2015Article
- Effect of Hibiscus sabdariffa extract on high fat diet-induced obesity and liver damage in hamsters.Food & nutrition research · 2015Article
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Authors and funding
6 authors.
Funding
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Abstract
This study investigated the effects of combined grape pomace and omija fruit extracts (GO) on diabetes-related metabolic changes in type 2 diabetic db/db mice. The effects of GO were compared with those of a resveratrol and schizandrin mixture (RS), which is a mixture of major components of GO. Mice were fed a normal diet with RS (0.005% resveratrol and 0.02% schizandrin in diet, w/w) or GO (0.3% grape pomace ethanol extract and 0.05% omija fruit ethanol extract in diet, w/w) for seven weeks. RS and GO not only lowered the levels of blood and plasma glucose, HbA1c, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) with a simultaneous decrease in hepatic gluconeogenic enzymes activities and adiposity, but also improved preservation of the pancreatic β-cells. Plasma leptin and resistin levels were lower while the plasma adiponectin level was higher in the RS and GO groups than in the control group. Especially, GO increased hepatic glucokinase activity and gene expression and improved hepatic steatosis by elevating fatty acid oxidation compared to RS. These findings suggest that GO ameliorates hyperglycemia, adiposity and hepatic steatosis in type 2 diabetic mice.
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