Evidence map›Paper›PMID 25272201›Full record

ArticlePsychosomatic medicine2014

Childhood socioeconomic disadvantage and prediabetes and diabetes in later life: a study of biopsychosocial pathways.

Vera Tsenkova, Tetyana Pudrovska, Arun Karlamangla

Abstract read
In one paragraph

Article in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Childhood socioeconomic position and adult leisure-time physical activity: a systematic review.The international journal of behavioral nutrition and physical activity · 2015
    Pooled it
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  14. Life Course Socioeconomic Status, Daily Stressors, and Daily Well-Being: Examining Chain of Risk Models.The journals of gerontology. Series B, Psychological sciences and social sciences · 2019
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  20. Baby Boomers and Birth Certificates: Early-Life Socioeconomic Status and Cancer Risk in Adulthood.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vera TsenkovaFrom the Center for Women's Health and Health Disparities Research (V.T.), University of Wisconsin-Madison, Madison, Wisconsin; Department of Sociology, (T.P.), University of Texas at Austin, Austin, Texas; and Department of Medicine (A.K.), UCLA, Los Angeles, California.
Tetyana Pudrovska
Arun Karlamangla

Funding

STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
WIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009
$6.9M
Biopsychosocial Pathways to Type 2 DiabetesK01AG041179 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI TSENKOVA, VERA K · 2012 to 2016
$539k
Childhood Socioeconomic Status and Late-Life Mortality: Sex and Race DifferencesR03AG040037 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI PUDROVSKA, TETYANA · 2011 to 2012
$122k
NCATS NIH HHS UL1 TR000427NCRR NIH HHS 1UL1RR025011NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR00865NCRR NIH HHS M01 RR023942NCRR NIH HHS M01-RR023942NCRR NIH HHS UL1 RR025011NIA NIH HHS K01 AG041179NIA NIH HHS K01AG041179NIA NIH HHS P01 AG020166NIA NIH HHS P01-AG020166NIA NIH HHS R03 AG040037NIA NIH HHS R03AG040037
6 · The paper itself

Abstract

objectiveWe examined the relationship between childhood socioeconomic status (SES) and glucoregulation in later life and used a life-course framework to examine critical periods and underlying pathways.

methodsData came from the Midlife in the US (MIDUS) national study (n = 895). Childhood SES indicators retrospectively reported at MIDUS I were used to create a childhood SES disadvantage index. Adult SES disadvantage and potential pathways were measured at MIDUS I and included waist circumference, depressive symptoms, and physical activity. Glucose and hemoglobin A1c, measured approximately 9 to 10 years later at MIDUS II, were used to create the ordinal outcome measure (no diabetes/prediabetes/diabetes).

resultsChildhood SES disadvantage predicted increased odds of prediabetes and diabetes net of age, sex, race, and smoking (odds ratio = 1.11, 95% confidence interval = 1.01-1.22). Childhood SES disadvantage predicted adult SES disadvantage (β = .26, p = .001) and the three key mediators: waist circumference (β = 0.10, p = .002), physical activity (β = -0.11, p = .001), and depressive symptoms (β = 0.07, p = .072). When childhood and adult SES disadvantage were in the same model, only adult SES predicted glucoregulation (odds ratio = 1.07, 95% confidence interval = 1.01-1.13). The SES disadvantage measures were no longer significantly associated with glucoregulation after including waist circumference, physical activity, and depressive symptoms, all of which were significant predictors of glucoregulation.

conclusionsThe consequences of childhood SES disadvantage are complex and include both critical period and pathway effects. The lack of a direct effect of childhood SES on glucoregulation does not negate the importance of early environment but suggests that early-life socioeconomic factors propel unequal life-course trajectories that ultimately influence health.

Indexed as

AdultAgedBlood GlucoseChildDepressionDiabetes MellitusFemaleGlycated HemoglobinHumansLongitudinal StudiesMaleMiddle AgedMotor ActivityPrediabetic StatePsychologyRetrospective StudiesBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID25272201
PMCPMC4229367

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.