ArticlePloS one2014
QTL analysis and candidate gene mapping for the polyphenol content in cider apple.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- A bittersweet symphony: genetic insights into cider apple fruit quality.G3 (Bethesda, Md.) · 2026Article
- Untargeted metabolomic genome-wide association study reveals genetic and biochemical insights into polyphenols of apple fruit.Horticulture research · 2025Article
- Enhanced scab resistance in apple conferred by Rvi6 and polyploidy is linked with distinct shifts in the phenolics profile.Scientific reports · 2025Article
- Reduced apple crop density enhances total polyphenol accumulation via upregulation of anthocyanidin reductase and other phenylpropanoid pathway genes.Frontiers in plant science · 2025Article
- Tracing the color: quantitative trait loci analysis reveals new insights into red-flesh pigmentation in apple (Horticulture research · 2024Article
- GWAS provides new insights into the genetic mechanisms of phytochemicals production and red skin colour in apple.Horticulture research · 2022Article
- Review
- Combining QTL Mapping and Transcriptomics to Decipher the Genetic Architecture of Phenolic Compounds Metabolism in the Conifer White Spruce.Frontiers in plant science · 2021Article
- Detection of Quantitative TraitFrontiers in plant science · 2021Article
- Phased diploid genome assemblies and pan-genomes provide insights into the genetic history of apple domestication.Nature genetics · 2020Article
- Resource allocation trade-offs and the loss of chemical defences during apple domestication.Annals of botany · 2019Article
- Multifaceted analyses disclose the role of fruit size and skin-russeting in the accumulation pattern of phenolic compounds in apple.PloS one · 2019Article
- Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols.Horticulture research · 2019Article
- Biotechnology and apple breeding in Japan.Breeding science · 2016Review
- Article
- Genomic basis of the differences between cider and dessert apple varieties.Evolutionary applications · 2015Article
- A major QTL controlling apple skin russeting maps on the linkage group 12 of 'Renetta Grigia di Torriana'.BMC plant biology · 2015Article
- Molecular characterization of genes encoding leucoanthocyanidin reductase involved in proanthocyanidin biosynthesis in apple.Frontiers in plant science · 2015Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphenols have favorable antioxidant potential on human health suggesting that their high content is responsible for the beneficial effects of apple consumption. They control the quality of ciders as they predominantly account for astringency, bitterness, color and aroma. In this study, we identified QTLs controlling phenolic compound concentrations and the average polymerization degree of flavanols in a cider apple progeny. Thirty-two compounds belonging to five groups of phenolic compounds were identified and quantified by reversed phase liquid chromatography on both fruit extract and juice, over three years. The average polymerization degree of flavanols was estimated in fruit by phloroglucinolysis coupled to HPLC. Parental maps were built using SSR and SNP markers and used for the QTL analysis. Sixty-nine and 72 QTLs were detected on 14 and 11 linkage groups of the female and male maps, respectively. A majority of the QTLs identified in this study are specific to this population, while others are consistent with previous studies. This study presents for the first time in apple, QTLs for the mean polymerization degree of procyanidins, for which the mechanisms involved remains unknown to this day. Identification of candidate genes underlying major QTLs was then performed in silico and permitted the identification of 18 enzymes of the polyphenol pathway and six transcription factors involved in the apple anthocyanin regulation. New markers were designed from sequences of the most interesting candidate genes in order to confirm their co-localization with underlying QTLs by genetic mapping. Finally, the potential use of these QTLs in breeding programs is discussed.
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