Evidence map›Paper›PMID 25271436›Full record

ReviewCritical reviews in oncogenesis2014

Development of nanoscale approaches for ovarian cancer therapeutics and diagnostics.

Sarah A Engelberth, Nadine Hempel, Magnus Bergkvist

Open access · greenAbstract readReview
In one paragraph

Review in Critical reviews in oncogenesis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Emerging Research and Future Directions on Doxorubicin: A Snapshot.Asian Pacific journal of cancer prevention : APJCP · 2025
    Review
  7. Review
  8. Review
  9. Current Update on Nanotechnology-Based Approaches in Ovarian Cancer Therapy.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Review
  10. Local Drug Delivery Strategies for Glioblastoma Treatment.Brain tumor research and treatment · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. What is new about ovarian malignancies?Contemporary oncology (Poznan, Poland) · 2021
    Review
  15. Article
  16. Article
  17. Nanotechnology and Immunotherapy in Ovarian Cancer: Tracing New Landscapes.The Journal of pharmacology and experimental therapeutics · 2019
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sarah A EngelberthSUNY College of Nanoscale Science and Engineering, Albany NY 12203.
Nadine HempelSUNY College of Nanoscale Science and Engineering, Albany NY 12203.
Magnus BergkvistSUNY College of Nanoscale Science and Engineering, Albany NY 12203.
Purchase College · US

Funding

Mitochondrial Redox Control of MetastasisR00CA143229 · NCI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI HEMPEL, NADINE · 2012 to 2014
$709k
NCI NIH HHS R00 CA143229NCI NIH HHS R00CA143229
6 · The paper itself

Abstract

Ovarian cancer is the deadliest of all gynecological cancers and the fifth leading cause of death due to cancer in women. This is largely due to late-stage diagnosis, poor prognosis related to advanced-stage disease, and the high recurrence rate associated with development of chemoresistance. Survival statistics have not improved significantly over the last three decades, highlighting the fact that improved therapeutic strategies and early detection require substantial improvements. Here, we review and highlight nanotechnology-based approaches that seek to address this need. The success of Doxil, a PEGylated liposomal nanoencapsulation of doxorubicin, which was approved by the FDA for use on recurrent ovarian cancer, has paved the way for the current wave of nanoparticle formulations in drug discovery and clinical trials. We discuss and summarize new nanoformulations that are currently moving into clinical trials and highlight novel nanotherapeutic strategies that have shown promising results in preclinical in vivo studies. Further, the potential for nanomaterials in diagnostic imaging techniques and the ability to leverage nanotechnology for early detection of ovarian cancer are also discussed.

Indexed as

NanotechnologyChemistry, PharmaceuticalFemaleHumansLiposomesOvarian NeoplasmsLiposomes

Identifiers

PMID25271436
PMCPMC4183979
OpenAlexW1997934415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.