ArticlePloS one2014
Selection pressure in alternative reading frames.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Frameshift mutations in theAntimicrobial agents and chemotherapy · 2024Article
- How antisense transcripts can evolve to encode novel proteins.Nature communications · 2024Article
- Three Novel Antisense Overlapping Genes in E. coli O157:H7 EDL933.Microbiology spectrum · 2023Article
- Protein-Coding Genes ofGenes · 2021Article
- Frame-shifted proteins of a given gene retain the same function.Nucleic acids research · 2020Article
- Asymmetric evolution in viral overlapping genes is a source of selective protein adaptation.Virology · 2019Article
- A Simple Method to Detect Candidate Overlapping Genes in Viruses Using Single Genome Sequences.Molecular biology and evolution · 2018Article
- The Novel Anaerobiosis-Responsive Overlapping GeneFrontiers in microbiology · 2018Article
- Genotype-Specific Evolution of Hepatitis E Virus.Journal of virology · 2017Article
- Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overlapping genes are two protein-coding sequences sharing a significant part of the same DNA locus in different reading frames. Although in recent times an increasing number of examples have been found in bacteria the underlying mechanisms of their evolution are unknown. In this work we explore how selective pressure in a protein-coding sequence influences its overlapping genes in alternative reading frames. We model evolution using a time-continuous Markov process and derive the corresponding model for the remaining frames to quantify selection pressure and genetic noise. Our findings lead to the presumption that, once information is embedded in the reverse reading frame -2 (relative to the mother gene in +1) purifying selection in the protein-coding reading frame automatically protects the sequences in both frames. We also found that this coincides with the fact that the genetic noise measured using the conditional entropy is minimal in frame -2 under selection in the coding frame.
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Registered trials
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