Evidence map›Paper›PMID 25271209›Full record

Observational studyJournal of the American Heart Association2014

Effect of low perceived social support on health outcomes in young patients with acute myocardial infarction: results from the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients) study.

Emily M Bucholz, Kelly M Strait, Rachel P Dreyer, Mary Geda, Erica S Spatz, Hector Bueno, Judith H Lichtman, Gail D'Onofrio, John A Spertus, Harlan M Krumholz

Abstract readComparative StudyEvaluation StudyObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Social Support and 10-Year Mortality Following Acute Myocardial Infarction.Journal of cardiovascular development and disease · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Review
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  18. Observational
  19. Comparisons of Patients Living Alone versus Living with Others in Acute Coronary Syndrome.The International journal of angiology : official publication of the International College of Angiology, Inc · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily M BucholzYale University School of Medicine, New Haven, CT (E.M.B.) Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT (E.M.B., J.H.L.).
Kelly M StraitCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (K.M.S., R.P.D., M.G., E.S.S., H.M.K.).
Rachel P DreyerCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (K.M.S., R.P.D., M.G., E.S.S., H.M.K.).
Mary GedaCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (K.M.S., R.P.D., M.G., E.S.S., H.M.K.).
Erica S SpatzCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (K.M.S., R.P.D., M.G., E.S.S., H.M.K.) Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, Madrid, Spain (E.S.S., H.M.K.).
Hector BuenoDepartment of Cardiology, Hospital General Universitario "Gregario Maraon", Madrid, Spain (H.B.).
Judith H LichtmanDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT (E.M.B., J.H.L.).
Gail D'OnofrioDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, CT (G.O.).
John A SpertusMid-America Heart Institute, University of Missouri-Kansas City Kansas City, MO (J.A.S.).
Harlan M KrumholzRobert Wood Johnson Foundation Clinical Scholars Program, Departments of Internal Medicine and Health Policy and Management, Yale School of Public Health, New Haven, CT (H.M.K.) Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (K.M.S., R.P.D., M.G., E.S.S., H.M.K.) Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, Madrid, Spain (E.S.S., H.M.K.).

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Young Women With Acute Myocardial InfarctionR01HL081153 · NHLBI · YALE UNIVERSITY · PI KRUMHOLZ, HARLAN MARC · 2007 to 2012
$10.6M
Center for Cardiovascular Outcomes Research at Yale UniversityU01HL105270 · NHLBI · YALE UNIVERSITY · PI CURTIS, JEPTHA PELHAM, KRUMHOLZ, HARLAN MARC · 2010 to 2013
$5.8M
HEARTLAND INSTITUTE FOR CLINICAL AND TRANSLATIONAL RESEARCHUL1RR033179 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BAROHN, RICHARD J. · 2011 to 2011
$3.2M
NCRR NIH HHS UL1 RR033179NHLBI NIH HHS 1U01HL105270-05NHLBI NIH HHS R01 HL081153NHLBI NIH HHS R01 HL081153-01A1KNHLBI NIH HHS U01 HL105270NIGMS NIH HHS T32 GM007205PHS HHS 1ULRR033179
6 · The paper itself

Abstract

backgroundSocial support is an important predictor of health outcomes after acute myocardial infarction (AMI), but social support varies by sex and age. Differences in social support could account for sex differences in outcomes of young patients with AMI. METHODS AND

resultsData from the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study, an observational study of AMI patients aged ≤55 years in the United States and Spain, were used for this study. Patients were categorized as having low versus moderate/high perceived social support using the ENRICHD Social Support Inventory. Outcomes included health status (Short Form-12 physical and mental component scores), depressive symptoms (Patient Health Questionnaire), and angina-related quality of life (Seattle Angina Questionnaire) evaluated at baseline and 12 months. Among 3432 patients, 21.2% were classified as having low social support. Men and women had comparable levels of social support at baseline. On average, patients with low social support reported lower functional status and quality of life and more depressive symptoms at baseline and 12 months post-AMI. After multivariable adjustment, including baseline health status, low social support was associated with lower mental functioning, lower quality of life, and more depressive symptoms at 12 months (all P<0.001). The relationship between low social support and worse physical functioning was nonsignificant after adjustment (P=0.6). No interactions were observed between social support, sex, or country.

conclusionLower social support is associated with worse health status and more depressive symptoms 12 months after AMI in both young men and women. Sex did not modify the effect of social support.

Indexed as

Health StatusQuality of LifeSocial SupportAdultAge FactorsChi-Square DistributionCohort StudiesFemaleHumansMaleMental HealthMiddle AgedMyocardial InfarctionPatient Outcome AssessmentPerceptionProspective Studiesmyocardial infarctionprognosissex

Identifiers

PMID25271209
PMCPMC4323798

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.