ArticleThe Journal of biological chemistry2014
Class IIa histone deacetylases are conserved regulators of circadian function.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Hepatocellular Carcinoma Around the Clock.Current oncology (Toronto, Ont.) · 2026Review
- A Quantitative Model of Sporadic Axonal Degeneration in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Integration of Circadian Clock Information in theJournal of biological rhythms · 2021Review
- Epigenetic regulation of post-embryonic development.Current opinion in insect science · 2021Review
- Critical review of non-histone human substrates of metal-dependent lysine deacetylases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Review
- Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020Review
- Article
- Analysing the evolutional and functional differentiation of four types of Daphnia magna cryptochrome in Drosophila circadian clock.Scientific reports · 2019Article
- Article
- Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.Cold Spring Harbor perspectives in biology · 2018Review
- Article
- Article
- Circadian Rhythms in Visual Responsiveness in the Behaviorally Arrhythmic Drosophila Clock Mutant ClkJournal of biological rhythms · 2017Article
- SIK3-HDAC4 signaling regulatesProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- mPer1 promotes morphine-induced locomotor sensitization and conditioned place preference via histone deacetylase activity.Psychopharmacology · 2017Article
- Hsp70/J-protein machinery from Glossina morsitans morsitans, vector of African trypanosomiasis.PloS one · 2017Article
- The molecular basis of metabolic cycles and their relationship to circadian rhythms.Nature structural & molecular biology · 2016Review
- Diurnal Variations of Human Circulating Cell-Free Micro-RNA.PloS one · 2016Article
- Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal.Molecules and cells · 2016Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Class IIa histone deacetylases (HDACs) regulate the activity of many transcription factors to influence liver gluconeogenesis and the development of specialized cells, including muscle, neurons, and lymphocytes. Here, we describe a conserved role for class IIa HDACs in sustaining robust circadian behavioral rhythms in Drosophila and cellular rhythms in mammalian cells. In mouse fibroblasts, overexpression of HDAC5 severely disrupts transcriptional rhythms of core clock genes. HDAC5 overexpression decreases BMAL1 acetylation on Lys-537 and pharmacological inhibition of class IIa HDACs increases BMAL1 acetylation. Furthermore, we observe cyclical nucleocytoplasmic shuttling of HDAC5 in mouse fibroblasts that is characteristically circadian. Mutation of the Drosophila homolog HDAC4 impairs locomotor activity rhythms of flies and decreases period mRNA levels. RNAi-mediated knockdown of HDAC4 in Drosophila clock cells also dampens circadian function. Given that the localization of class IIa HDACs is signal-regulated and influenced by Ca(2+) and cAMP signals, our findings offer a mechanism by which extracellular stimuli that generate these signals can feed into the molecular clock machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.