ArticleEuropean journal of clinical nutrition2015
Alpha-linolenic acid (ALA) is inversely related to development of adiposity in school-age children.
Article in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Maximal exercise and erythrocyte fatty-acid status: a lipidomics study.Physiological reports · 2019Trial
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- Evening primrose oil ameliorates tissue architecture, apoptosis, and oxidative stress in the pancreas of diabetic rats: Possible role of miR-21.Iranian journal of basic medical sciences · 2024Article
- New Perspectives on the Associations between Blood Fatty Acids, Growth Parameters, and Cognitive Development in Global Child Populations.Nutrients · 2023Review
- Differential Association of Dietary Linoleic Acid and Alpha-linolenic Acid with Adipose Tissue in a Sample of Iranian Adults; A Cohort-based Cross-sectional Study.Galen medical journal · 2023Article
- Implications of Nutritional Management on Fatty Acid Profiles of Southern White Rhinoceroses (Animals : an open access journal from MDPI · 2021Article
- Plasma lipids and growth faltering: A longitudinal cohort study in rural Gambian children.Science advances · 2021Article
- Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence.Metabolites · 2020Article
- In utero exposure to gestational diabetes mellitus and cardiovascular risk factors in youth: A longitudinal analysis in the EPOCH cohort.Pediatric obesity · 2020Article
- Polyunsaturated fatty acids in middle childhood and externalizing and internalizing behavior problems in adolescence.European journal of clinical nutrition · 2020Article
- Effects of hemodialysis on blood fatty acids.Physiological reports · 2020Article
- Food-Intake Normalization of Dysregulated Fatty Acids in Women with Anorexia Nervosa.Nutrients · 2019Article
- Integrated analysis of transcriptomic and proteomic data from tree peony (Horticulture research · 2019Article
- Serum Polyunsaturated Fatty Acids in Middle Childhood and Body Mass Index Change Through Adolescence.Annals of nutrition & metabolism · 2019Article
- Serum Trans Fatty Acids Are Not Associated with Weight Gain or Linear Growth in School-Age Children.The Journal of nutrition · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesStudies in adults indicate that dietary polyunsaturated fatty acid (PUFA) composition may play a role in development of adiposity. Because adipocyte quantity is established between late childhood and early adolescence, understanding the impact of PUFAs on weight gain during the school-age years is crucial to developing effective interventions. SUBJECTS/
methodsWe quantified N-3 and N-6 PUFAs in serum samples of 668 Colombian schoolchildren aged 5-12 years at the time of recruitment into a cohort study, using gas-liquid chromatography. Serum concentrations of N-3 (alpha-linolenic acid (ALA), eicosapentaenoic acid, docosahexaenoic acid) and N-6 PUFAs (linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid) were determined as percentage total fatty acids. Children's anthropometry was measured annually for a median of 30 months. We used mixed-effects models with restricted cubic splines to construct population body mass index-for-age z-score (BAZ) growth curves for age- and sex-specific quartiles of each PUFA.
resultsN-3 ALA was inversely related to BAZ gain after adjustment for sex, baseline age and weight status, as well as household socioeconomic level. Estimated BAZ change between 6 and 14 years among children in the highest quartile of ALA compared with those in the lowest quartile was 0.45 (95% confidence interval: 0.07, 0.83) lower (P-trend=0.006).
conclusionsN-3 ALA may be protective against weight gain in school-age children. Whether improvement in PUFA status reduces adiposity in pediatric populations deserves evaluation in randomized trials.
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