ArticleJournal of thrombosis and thrombolysis2015
Differing coagulation profiles of patients with monoclonal gammopathy of undetermined significance and multiple myeloma.
Article in Journal of thrombosis and thrombolysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Cytomegalovirus infection with pulmonary embolism, splenic vein thrombosis and monoclonal gammopathy of undetermined significance: a case and systematic review.BMJ case reports · 2019Pooled it
- Diagnostic and therapeutic challenges in rare hematologic entities: monoclonal gammopathy of thrombotic and bleeding significance.Haematologica · 2026Review
- A Multi-Omics and machine learning platelet-related prognostic signature in multiple myeloma.Annals of hematology · 2026Article
- Estimated Whole Blood Viscosity in Smoldering Multiple Myeloma: Preliminary Data from a Retrospective Single Center Analysis.Journal of blood medicine · 2026Article
- Coagulation profile in bitches with pyometra: Standard tests and thromboelastography.Veterinarni medicina · 2025Article
- Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights.Journal of cardiovascular development and disease · 2023Review
- Monoclonal Gammopathy of Thrombotic Significance.Cancers · 2023Review
- The role of VWF/FVIII in thrombosis and cancer progression in multiple myeloma and other hematological malignancies.Journal of thrombosis and haemostasis : JTH · 2022Review
- Incidence of Venous Thromboembolism in Multiple Myeloma Patients across Different Regimens: Role of Procoagulant Microparticles and Cytokine Release.Journal of clinical medicine · 2022Article
- Analysis of Coagulation Abnormality in Patients with Multiple Myeloma and Its Clinical Significance.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Risk Factors for Catheter-Related Thrombosis in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation.Medicina (Kaunas, Lithuania) · 2021Article
- The Prognostic Role of Prothrombin Time and Activated Partial Thromboplastin Time in Patients with Newly Diagnosed Multiple Myeloma.BioMed research international · 2021Article
- Thrombosis Risk Associated with Head and Neck Cancer: A Review.International journal of molecular sciences · 2019Review
- Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review.Seminars in thrombosis and hemostasis · 2019Review
- Article
- Evaluation of thromboelastography in bitches with pyometra.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- Network-based analysis of the molecular mechanisms of multiple myeloma and monoclonal gammopathy of undetermined significance.Oncology letters · 2017Article
Corrections and comments
- Erratum issuedErratum to: Differing coagulation profiles of patients with monoclonal gammopathy of undetermined significance and multiple myeloma.2015 · Crowely, Maeve P [corrected to Crowley, Maeve P];Shea, Susan I O [corrected to O'Shea, Susan I]
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The link between myeloma and thrombosis is well established. Monoclonal gammopathy of undetermined significance (MGUS) has also been associated with an increased risk of thrombosis. It was recently demonstrated that patients with myeloma display changes in thromboelastometry that may indicate a prothrombotic state. There is little data with regard to changes in thromboelastography in patients with myeloma or MGUS. The aim of this study was to investigate the differing coagulation profiles of patients of patients with myeloma and MGUS by means of conventional coagulation tests and thromboelastography. Blood was taken by direct venepuncture from patients with myeloma, MGUS and normal controls. Routine coagulation tests were performed in an accredited hospital laboratory. Thromboelastography (TEG(®)) was performed as per the manufacturer's protocol. Eight patients were recruited in each group. Patients with myeloma had a significantly lower mean haemoglobin level than patients with MGUS or normal controls (p < 0.001). Patients with myeloma had a significantly more prolonged mean prothrombin time than normal controls (p = 0.018) but not patients with MGUS. Patients with myeloma had significantly higher median D-dimer levels than normal controls (p = 0.025), as did patients with MGUS (p = 0.017). Patients with myeloma had a significantly higher mean factor VIII level than normal controls (p = 0.009) and there was a non-significant trend towards patients with MGUS having higher factor VIII levels than normal controls (p = 0.059). There was no significant difference in thromboelastographic parameters between the three groups. Patients with MGUS appear to have a distinct coagulation profile which is intermediate between patients with myeloma and normal controls.
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Registered trials
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