ArticleMethods in molecular biology (Clifton, N.J.)2014
Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry.
Article in Methods in molecular biology (Clifton, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Macronutrient, Energy, and Bile Acid Metabolism Pathways Altered Following a Physiological Meal Challenge, Relative to Fasting, among Guatemalan Adults.The Journal of nutrition · 2020Trial
- Overview of methods that determine mitochondrial function in human disease.Metabolism: clinical and experimental · 2025Review
- The Peptide Fractions of Cheddar Cheese Made withFoods (Basel, Switzerland) · 2023Article
- Chronic ethanol exposure induces mitochondrial dysfunction and alters gene expression and metabolism in human cardiac spheroids.Alcohol, clinical & experimental research · 2023Article
- Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.Nature metabolism · 2021Article
- Clinical Insights into Mitochondrial Neurodevelopmental and Neurodegenerative Disorders: Their Biosignatures from Mass Spectrometry-Based Metabolomics.Metabolites · 2021Review
- Metabolomic Profiling After a Meal Shows Greater Changes and Lower Metabolic Flexibility in Cardiometabolic Diseases.Journal of the Endocrine Society · 2020Article
- Metabolic Modelling as a Framework for Metabolomics Data Integration and Analysis.Metabolites · 2020Review
- Novel mitochondrial and cytosolic purification pipeline for compartment-specific metabolomics in mammalian disease model tissues.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury.Cell metabolism · 2020Article
- Omics Integration for Mitochondria Systems Biology.Antioxidants & redox signaling · 2020Review
- Studying the Exposome to Understand the Environmental Determinants of Complex Liver Diseases.Hepatology (Baltimore, Md.) · 2020Review
- A precision medicine approach to defining the impact of doxorubicin on the bioenergetic-metabolite interactome in human platelets.Redox biology · 2020Article
- Metabolomic Responses to Manganese Dose in SH-SY5Y Human Neuroblastoma Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets.Redox biology · 2019Article
- The metabolome as a biomarker of mortality risk in the common marmoset.American journal of primatology · 2019Article
- Phytochelatin database: a resource for phytochelatin complexes of nutritional and environmental metals.Database : the journal of biological databases and curation · 2019Article
- Selenium at the redox interface of the genome, metabolome and exposome.Free radical biology & medicine · 2018Review
- Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Biomonitoring in the Era of the Exposome.Environmental health perspectives · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
High-resolution Fourier-transform mass spectrometry (FTMS) provides important advantages in studies of metabolism because more than half of common intermediary metabolites can be measured in 10 min with minimal pre-detector separation and without ion dissociation. This capability allows unprecedented opportunity to study complex metabolic systems, such as mitochondria. Analysis of mouse liver mitochondria using FTMS with liquid chromatography shows that sex and genotypic differences in mitochondrial metabolism can be readily distinguished. Additionally, differences in mitochondrial function are readily measured, and many of the mitochondria-related metabolites are also measurable in plasma. Thus, application of high-resolution mass spectrometry provides an approach for integrated studies of complex metabolic processes of mitochondrial function and dysfunction in disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.