Evidence map›Paper›PMID 25270853›Full record

ArticleBMJ open2014

Change in prevalence of chronic kidney disease in England over time: comparison of nationally representative cross-sectional surveys from 2003 to 2010.

Grant R Aitken, Paul J Roderick, Simon Fraser, Jennifer S Mindell, Donal O'Donoghue, Julie Day, Graham Moon

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Enhanced Invitations Using the Question-Behavior Effect and Financial Incentives to Promote Health Check Uptake in Primary Care.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018
    Trial
  4. Trial
  5. Article
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  9. Epidemiology of chronic kidney disease: an update 2022.Kidney international supplements · 2022 · on this map
    Review
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020
    Observational
  17. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Grant R AitkenFaculty of Social and Human Sciences, Department of Geography, University of Southampton, Southampton, UK.
Paul J RoderickFaculty of Medicine, Academic Unit of Primary Care and Population Sciences, University of Southampton, Southampton, UK.
Simon FraserFaculty of Medicine, Academic Unit of Primary Care and Population Sciences, University of Southampton, Southampton, UK.
Jennifer S MindellResearch Department of Epidemiology and Public Health, University College London, London, UK.
Donal O'DonoghueRenal Unit, Salford Royal NHS Foundation Trust, Salford, UK.
Julie DayDepartment of Clinical Biochemistry, Royal Victoria Infirmary, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Graham MoonFaculty of Social and Human Sciences, Department of Geography, University of Southampton, Southampton, UK.
University of Southampton · GBRoyal Victoria Infirmary · GBSalford Royal NHS Foundation Trust · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine whether the prevalence of chronic kidney disease (CKD) in England has changed over time.

designCross-sectional analysis of nationally representative Health Survey for England (HSE) random samples.

settingEngland 2003 and 2009/2010. SURVEY

participants13,896 adults aged 16+ participating in HSE, adjusted for sampling and non-response, 2009/2010 surveys combined.

main outcome measureChange in prevalence of estimated glomerular filtration rate (eGFR)<60 mL/min/1.73 m2 (as proxy for stage 3-5 CKD), from 2003 to 2009/2010 based on a single serum creatinine measure using an isotope dilution mass spectrometry traceable enzymatic assay in a single laboratory; eGFR derived using Modified Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) eGFR formulae. ANALYSIS: Multivariate logistic regression modelling to adjust time changes for sociodemographic and clinical factors (body mass index, hypertension, diabetes, lipids). A correction factor was applied to the 2003 HSE serum creatinine to account for a storage effect.

resultsNational prevalence of low eGFR (<60) decreased within each age and gender group for both formulae except in men aged 65-74. Prevalence of obesity and diabetes increased in this period, while there was a decrease in hypertension. Adjustment for demographic and clinical factors led to a significant decrease in CKD between the surveyed periods. The fully adjusted OR for eGFR<60 mL/min/1.73 m2 was 0.75 (0.61 to 0.92) comparing 2009/2010 with 2003 using the MDRD equation, and was similar using the CKDEPI equation 0.73 (0.57 to 0.93).

conclusionsThe prevalence of a low eGFR indicative of CKD in England appeared to decrease over this 7-year period, despite the rising prevalence of obesity and diabetes, two key causes of CKD. Hypertension prevalence declined and blood pressure control improved but this did not appear to explain the fall. Periodic assessment of eGFR and albuminuria in future HSEs is needed to evaluate trends in CKD.

Indexed as

AdolescentAdultAgedAge FactorsCross-Sectional StudiesEnglandFemaleGlomerular Filtration RateHealth SurveysHumansLogistic ModelsMaleMiddle AgedPrevalenceRenal Insufficiency, ChronicRisk FactorsEPIDEMIOLOGYPUBLIC HEALTH

Identifiers

PMID25270853
PMCPMC4179568
OpenAlexW2111432918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.