Observational studyObesity surgery2015
Effectiveness of B vitamin supplementation following bariatric surgery: rapid increases of serum vitamin B12.
Observational study in Obesity surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Iron, Vitamin BObesity surgery · 2020 · on this mapPooled it
- Pooled it
- Does Bariatric Surgery Cause Vitamin A, B1, C or E Deficiency? A Systematic Review.Obesity surgery · 2018Pooled it
- Vitamin D supplementation for the prevention of vitamin D deficiency after bariatric surgery: a systematic review and meta-analysis.European journal of clinical nutrition · 2018Pooled it
- Oral Vitamin BObesity surgery · 2018Pooled it
- Different Supplementation Regimes to Treat Perioperative Vitamin B12 Deficiencies in Bariatric Surgery: a Systematic Review.Obesity surgery · 2017Pooled it
- Effects of Metabolic Bariatric Surgery On Micronutrient Status in Chinese Patients With Obesity: A 12-month Follow-up Study.Obesity surgery · 2026Article
- A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements.Current nutrition reports · 2025Review
- The effect of bariatric surgery on dietary Behaviour, dietary recommendation Adherence, and micronutrient deficiencies one year after surgery.Preventive medicine reports · 2023Article
- Etiology of serum vitamin B12 elevation 1 month after bariatric surgery: A case-control study based on China population.Medicine · 2021Article
- Review
- Review
- Total parenteral nutrition-induced Wernicke's encephalopathy after oncologic gastrointestinal surgery.Open medicine (Warsaw, Poland) · 2020Article
- Preventing Wernicke Encephalopathy After Bariatric Surgery.Obesity surgery · 2018Review
- Nutritional and Micronutrient Care of Bariatric Surgery Patients: Current Evidence Update.Current obesity reports · 2017Review
- Nutrient Deficiency 10 Years Following Roux-en-Y Gastric Bypass: Who's Responsible?Obesity surgery · 2017Article
- Gastrointestinal Transcriptomic Response of Metabolic Vitamin B12 Pathways in Roux-en-Y Gastric Bypass.Clinical and translational gastroenterology · 2017Article
- Patient-Reported Adherence to Empiric Vitamin/Mineral Supplementation and Related Nutrient Deficiencies After Roux-en-Y Gastric Bypass.Obesity surgery · 2016 · on this mapArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew prospective studies have compared changes of nutrient intake while assessing effectiveness of thiamin, vitamin B12, and folate supplementation to prevent B vitamin deficiencies immediately following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Therefore, we determined the response to 3 months supplementation on maintaining blood B vitamin concentrations.
methodsWomen undergoing RYGB (n = 11) and SG (n = 11) consumed bariatric vitamin supplements (12 mg thiamin, 350 μg vitamin B12, 800 μg folic acid) daily for 3 months. Height, weight, body mass index, and blood vitamin concentrations were measured preoperatively and at 3 months. Wilcoxon signed-rank analyses compared body weight parameters, laboratory indices, and nutrient intake at baseline and 3 months.
resultsSupplementation for 3 months maintained blood thiamin, increased serum folate from 13.1 ± 5.4 to 16.3 ± 6.0 nmol/L (P = 0.049), and increased serum vitamin B12 concentrations from 498 ± 150 to 736 ± 340 pg/mL (P = 0.005). Dietary intake of thiamin and folate decreased in the combined surgical groups, while dietary intake of B12 was maintained. Bariatric B vitamin supplements provided multiple intakes of the Recommended Dietary Allowances (1090% thiamin, 14,583% vitamin B12, 200% folate).
conclusionsAlthough energy intake decreased 64%, B vitamin supplementation for 3 months resulted in a 48% increase of serum vitamin B12, a modest increase of serum folate, and no reduction of blood thiamin concentrations. Long-term effects of the rapid rise of serum B12 levels attributed to the high content of supplements warrant further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.