ArticleJournal of the experimental analysis of behavior2014
Quantifying nicotine's value-enhancement effect using a behavioral economic approach.
Article in Journal of the experimental analysis of behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Possible New Symptoms of Tobacco Withdrawal II: Anhedonia-A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Pooled it
- Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.Neuropharmacology · 2022Article
- Reward-enhancing effects of d-amphetamine and its interactions with nicotine were greater in female rats and persisted across schedules of reinforcement.Behavioural pharmacology · 2021Article
- Behavioral economic measurement of cigarette demand: A descriptive review of published approaches to the cigarette purchase task.Experimental and clinical psychopharmacology · 2020Review
- Behavioral Economic Research in Addiction as an Area of Growth for the Experimental Analysis of Behavior.Behavior analysis (Washington, D.C.) · 2018Article
- A behavioral economic analysis of the value-enhancing effects of nicotine and varenicline and the role of nicotinic acetylcholine receptors in male and female rats.Behavioural pharmacology · 2018Article
- Article
- Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion.Psychopharmacology · 2017Article
- The effects of varenicline on methamphetamine self-administration and drug-primed reinstatement in female rats.Behavioural brain research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Nicotine increases the value of some reinforcing stimuli, and this effect may contribute to nicotine's widespread abuse. We aimed to quantify this effect using a behavioral economic analysis. Six Long- Evans rats were exposed to a modified observing response procedure. In this procedure, presses to one lever resulted either in food according to a variable-interval 15 s schedule or extinction; presses to a second, observing lever illuminated stimuli correlated with the schedule in effect on the food/extinction lever (i.e., conditioned reinforcers). The FR requirement on the observing lever increased across sessions. The number of presentations of the conditioned reinforcers was plotted as a function of FR value to generate a demand curve. Nicotine was then administered at a dose of 0.3 mg/kg. All demand curves were fitted to the exponential demand equation and a parameter reflecting reinforcer value was evaluated. Nicotine increased the value of the conditioned reinforcers as measured by this equation; nicotine also increased responding on the food/extinction lever. This analysis demonstrates that nicotine increases the value of conditioned reinforcers under certain conditions. The current procedure allows for a novel method of analyzing demand for conditioned reinforcers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.