ArticleArthritis research & therapy2014
Dynamic contrast-enhanced magnetic resonance imaging of metacarpophalangeal joints reflects histological signs of synovitis in rheumatoid arthritis.
Article in Arthritis research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 40 citations in OpenAlex.
- The association between articular calcium crystal deposition and knee osteoarthritis, joint pain and inflammation: a cross-sectional study.Skeletal radiology · 2025Trial
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- Dynamic contrast-enhanced (DCE) imaging: state of the art and applications in whole-body imaging.Japanese journal of radiology · 2022Review
- Article
- Voxel-based mapping of five MR biomarkers in the wrist bone marrow.Magma (New York, N.Y.) · 2021Article
- MRI wrist in early rheumatoid arthritis: reduction in inflammation assessed quantitatively during treatment period correlates best with clinical improvement.Skeletal radiology · 2021Article
- [Rheumatoid arthritis of the hand : Part 2: Imaging].Der Radiologe · 2021Review
- Differentiating rheumatoid and psoriatic arthritis: a systematic analysis of high-resolution magnetic resonance imaging features-preliminary findings.Skeletal radiology · 2021Article
- Color fraction as a useful method of imaging synovium vascularization in patients with high activity of rheumatoid arthritis.Reumatologia · 2020Review
- Cartilage Degradation in Psoriatic Arthritis Is Associated With Increased Synovial Perfusion as Detected by Magnetic Resonance Imaging.Frontiers in medicine · 2020Article
- MRI of synovitis and joint fluid.Journal of magnetic resonance imaging : JMRI · 2019Review
- Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy.Frontiers in medicine · 2019Review
- Clinical utility of eco-color-power Doppler ultrasonography and contrast enhanced magnetic resonance imaging for interpretation and quantification of joint synovitis: a review.Acta bio-medica : Atenei Parmensis · 2018Review
- Clinical applications of advanced magnetic resonance imaging techniques for arthritis evaluation.World journal of orthopedics · 2017Review
- Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritis.Osteoarthritis and cartilage · 2016Article
- Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis.Arthritis research & therapy · 2016Article
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11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionSynovial inflammation and joint destruction in rheumatoid arthritis (RA) may progress despite clinical remission. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is increasingly used to detect synovial inflammation in RA. Although small joints such as metacarpophalangeal (MCP) joints are mainly affected by RA, MRI findings have never been directly compared to histological synovitis in MCP synovial tissue. The objective of the current study was therefore to analyse if DCE-MRI relates to histological signs of synovitis small RA joints.
methodsIn 9 RA patients, DCE-MRI (3 Tesla, dynamic 2D T1 weighted turbo-flash sequence) of the hand was performed prior to arthroscopically-guided synovial biopsies from the second MCP of the imaged hand. Maximum enhancement (ME), rate of early enhancement, and maximum rate of enhancement were assessed in the MCP. Synovial biopsies were stained for determination of sublining CD68 and the Synovitis Score. Correlations between MRI and histological data were calculated according to Spearman.
resultsME of the MCP significantly correlated to sublining CD68 staining (r = 0.750, P = 0.02), the Synovitis Score (r = 0.743, P = 0.02), and the subscores for lining layer hypertrophy (r = 0.789, P = 0.01) and cellular density (r = 0.842; P = 0.004).
conclusionsPerfusion imaging of synovial tissue in RA finger joints employing DCE-MRI reflects histological synovial inflammation. According to our study, ME is the most closely associated parameter amongst the measures considered.
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