ArticleLasers in surgery and medicine2014
Topical rapamycin systematically suppresses the early stages of pulsed dye laser-induced angiogenesis pathways.
Article in Lasers in surgery and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- A Randomized Controlled Pilot Study: Combined 595-nm Pulsed Dye Laser Treatment and Oxymetazoline Hydrochloride Topical Cream Superior to Oxymetazoline Hydrochloride Cream for Erythematotelangiectatic Rosacea.Lasers in surgery and medicine · 2021Trial
- Computational modeling of oxygen dynamics in port-wine stain photodynamic therapy: treatment outcome optimization and pain management.Journal of biomedical optics · 2026Article
- Current clinical evidence is insufficient to support HMME-PDT as the first choice of treatment for young children with port wine birthmarks.Lasers in surgery and medicine · 2024Review
- Cell Populations Expressing Stemness-Associated Markers in Vascular Anomalies.Frontiers in surgery · 2020Review
- Site-specific pharmaco-laser therapy: A novel treatment modality for refractory port wine stains.Journal of clinical and translational research · 2019Review
- The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.International journal of molecular sciences · 2019Review
- Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels.Histology and histopathology · 2019Article
- Coexistence of Eph receptor B1 and ephrin B2 in port-wine stain endothelial progenitor cells contributes to clinicopathological vasculature dilatation.The British journal of dermatology · 2017Article
- Activation of PKCα and PI3K Kinases in Hypertrophic and Nodular Port Wine Stain Lesions.The American Journal of dermatopathology · 2017Article
- Ultrastructural characterization of hyperactive endothelial cells, pericytes and fibroblasts in hypertrophic and nodular port-wine stain lesions.The British journal of dermatology · 2017Article
- Pediatric Dermatology.The Journal of clinical and aesthetic dermatology · 2017Review
- Successful Treatment of Unilateral Klippel-Trenaunay Syndrome With Pulsed-Dye Laser in a 2-Week Old Infant.Journal of lasers in medical sciences · 2017Article
- Laser treatment of port-wine stains.Clinical, cosmetic and investigational dermatology · 2015Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundAdministration of topical rapamycin (RPM) suppresses the regeneration and revascularization of photocoagulated blood vessels induced by pulsed dye laser (PDL).
objectiveTo systematically elucidate the molecular pathophysiology of the inhibition of PDL-induced angiogenesis by topical RPM in a rodent model.
methodsThe mRNA expression profiles of 86 angiogenic genes and phosphorylation levels of ribosomal protein S6 kinase (P70S6K) in rodent skin were examined with or without topical RPM administration post-PDL exposure.
resultsThe PDL-induced systematic increases in transcriptional levels of angiogenic genes showed a peak expression at days 3-7 post-PDL in rodent skin. Topical application of 1% RPM significantly and systematically suppressed the PDL-induced increase in mRNA levels of the examined angiogenic genes during the first five days post-PDL. The phosphorylation levels of P70S6K increased after PDL exposure but those increases were suppressed by the topical RPM. After topical application, RPM penetrated to an approximate depth of 768.4 μm into rodent skin.
conclusionTopical application of 1% RPM can significantly and systematically suppress the PDL-induced early stage of angiogenesis via inhibition of the AKT/mTOR/P70S6K pathway in a rodent model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.