ArticleScientific reports2014
Improved assemblies using a source-agnostic pipeline for MetaGenomic Assembly by Merging (MeGAMerge) of contigs.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Exploring the Antimicrobial Potential of a Novel Phage-Derived Lytic Protein AgainstCurrent issues in molecular biology · 2026Article
- Enhanced mercury phytoremediation by Pseudomonodictys pantanalensis sp. nov. A73 and Westerdykella aquatica P71.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Article
- Metatranscriptomic Analysis of Bacterial Communities on Laundered Textiles: A Pilot Case Study.Microorganisms · 2021Article
- Article
- Metagenomic approaches in microbial ecology: an update on whole-genome and marker gene sequencing analyses.Microbial genomics · 2020Review
- Terabase-scale metagenome coassembly with MetaHipMer.Scientific reports · 2020Article
- Assessment of metagenomic assemblers based on hybrid reads of real and simulated metagenomic sequences.Briefings in bioinformatics · 2020Review
- Enteric Virome and Carcinogenesis in the Gut.Digestive diseases and sciences · 2020Review
- Functional screening of a soil metagenome for DNA endonucleases by acquired resistance to bacteriophage infection.Molecular biology reports · 2020Article
- Wetland Sediments Host Diverse Microbial Taxa Capable of Cycling Alcohols.Applied and environmental microbiology · 2019Article
- Viral and metabolic controls on high rates of microbial sulfur and carbon cycling in wetland ecosystems.Microbiome · 2018Article
- Analysis of Vibrio seventh pandemic island II and novel genomic islands in relation to attachment sequences among a wide variety of Vibrio cholerae strains.Microbiology and immunology · 2018Article
- Overview of Virus Metagenomic Classification Methods and Their Biological Applications.Frontiers in microbiology · 2018Review
- ICoVeR - an interactive visualization tool for verification and refinement of metagenomic bins.BMC bioinformatics · 2017Article
- Improved metagenome assemblies and taxonomic binning using long-read circular consensus sequence data.Scientific reports · 2016Article
- Review
- First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.Genome announcements · 2015Article
- Impact of library preparation protocols and template quantity on the metagenomic reconstruction of a mock microbial community.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assembly of metagenomic samples is a very complex process, with algorithms designed to address sequencing platform-specific issues, (read length, data volume, and/or community complexity), while also faced with genomes that differ greatly in nucleotide compositional biases and in abundance. To address these issues, we have developed a post-assembly process: MetaGenomic Assembly by Merging (MeGAMerge). We compare this process to the performance of several assemblers, using both real, and in-silico generated samples of different community composition and complexity. MeGAMerge consistently outperforms individual assembly methods, producing larger contigs with an increased number of predicted genes, without replication of data. MeGAMerge contigs are supported by read mapping and contig alignment data, when using synthetically-derived and real metagenomic data, as well as by gene prediction analyses and similarity searches. MeGAMerge is a flexible method that generates improved metagenome assemblies, with the ability to accommodate upcoming sequencing platforms, as well as present and future assembly algorithms.
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Registered trials
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